Mendelian randomization of plasma proteomics identifies novel ALS-associated proteins and their GO enrichment and KEGG pathway analyses

Mendelian randomization of plasma proteomics identifies novel ALS-associated proteins and their GO enrichment and KEGG pathway analyses

Abstract Background Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurological disorder with an increasing incidence rate. Despite advances in ALS research over the years, the precise etiology and pathogenic mechanisms remain largely elusive. Objective To identify novel plasma prote...

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Bibliographic Details
Main Authors: Chuan Lu, Xiao-xiao Huang, Ming Huang, Chaoning Liu, Jianwen Xu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Neurology
Subjects:
Amyotrophic lateral sclerosis
Plasma proteins
Mendelian randomization
GO functional analysis
KEGG pathway analysis
Drug target prediction
Online Access:https://doi.org/10.1186/s12883-025-04091-x
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