Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology
BackgroundAlthough protein supplementation may be desirable in the management of sarcopenia, the appropriate protein requirements for older adults with sarcopenia are presently unclear.ObjectiveThe aim of this study was to determine the protein requirements of older adults (65–81 year) with sarcopen...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1486482/full |
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| author | Wenxuan Wu Fengge Chen Hui Ma Jiaxi Lu Jiaxi Lu Yanhong Zhang Haisong Zhou Yunqi Yang Shuhui Nie Rui Wang Rui Wang Weixiao Yue Min Li Min Li Xiaoguang Yang Xiaoguang Yang |
| author_facet | Wenxuan Wu Fengge Chen Hui Ma Jiaxi Lu Jiaxi Lu Yanhong Zhang Haisong Zhou Yunqi Yang Shuhui Nie Rui Wang Rui Wang Weixiao Yue Min Li Min Li Xiaoguang Yang Xiaoguang Yang |
| author_sort | Wenxuan Wu |
| collection | DOAJ |
| description | BackgroundAlthough protein supplementation may be desirable in the management of sarcopenia, the appropriate protein requirements for older adults with sarcopenia are presently unclear.ObjectiveThe aim of this study was to determine the protein requirements of older adults (65–81 year) with sarcopenia by using the indicator amino acid oxidation (IAAO) technology.MethodsNine older adults with sarcopenia (four male participants and five female participants) participated in the study, with protein intakes ranging from 0.1 to 1.8 g/(kg·d). Each participant consumed an adapted diet with a protein level of 1.0 g/(kg·d) and 1.7 resting energy expenditure (REE) for 2 day. Day 3 was the oxidation day of the study. Diets that delivered energy at a 1.5 × REE were isocaloric. The amounts of phenylalanine and tyrosine maintained at a constant across intakes. Therefore, phenylalanine and tyrosine were added to the protein doses of 0.1–1.5 g/kg, which was based on the highest dose of lactalbumin content [1.8 g/(kg·d)]. Applying a non-linear mixed-effects model analysis of F13CO2, the protein requirement was determined by identifying the breakpoint in the F13CO2 data with graded amounts of dietary protein.ResultsThe mean estimated average requirement (EAR) and recommended nutrient intake (RNI) of protein for older adults with sarcopenia were 1.21 (95% CI: 0.95, 1.46) and 1.54 (95% CI: 1.13, 1.95) g/(kg·d), respectively.ConclusionsTo our knowledge, this is the first study of protein intake in older adults with sarcopenia and indicates that older adults with sarcopenia may require a higher intake of dietary protein.Clinical trial registrationhttp://www.chictr.org.cn, ChiCTR2200061383. |
| format | Article |
| id | doaj-art-2669a41dc8e4418c8ee90e0c35a8b4aa |
| institution | DOAJ |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-2669a41dc8e4418c8ee90e0c35a8b4aa2025-08-20T02:45:50ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.14864821486482Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technologyWenxuan Wu0Fengge Chen1Hui Ma2Jiaxi Lu3Jiaxi Lu4Yanhong Zhang5Haisong Zhou6Yunqi Yang7Shuhui Nie8Rui Wang9Rui Wang10Weixiao Yue11Min Li12Min Li13Xiaoguang Yang14Xiaoguang Yang15National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaShijiazhuang Center for Disease Control and Prevention, Shijiazhuang, Hebei, ChinaShijiazhuang Center for Disease Control and Prevention, Shijiazhuang, Hebei, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaKey Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China, Beijing, ChinaZhengding County Center for Disease Control and Prevention, Zhengding, Hebei, ChinaZhengding County Center for Disease Control and Prevention, Zhengding, Hebei, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaKey Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China, Beijing, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaKey Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China, Beijing, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaKey Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China, Beijing, ChinaBackgroundAlthough protein supplementation may be desirable in the management of sarcopenia, the appropriate protein requirements for older adults with sarcopenia are presently unclear.ObjectiveThe aim of this study was to determine the protein requirements of older adults (65–81 year) with sarcopenia by using the indicator amino acid oxidation (IAAO) technology.MethodsNine older adults with sarcopenia (four male participants and five female participants) participated in the study, with protein intakes ranging from 0.1 to 1.8 g/(kg·d). Each participant consumed an adapted diet with a protein level of 1.0 g/(kg·d) and 1.7 resting energy expenditure (REE) for 2 day. Day 3 was the oxidation day of the study. Diets that delivered energy at a 1.5 × REE were isocaloric. The amounts of phenylalanine and tyrosine maintained at a constant across intakes. Therefore, phenylalanine and tyrosine were added to the protein doses of 0.1–1.5 g/kg, which was based on the highest dose of lactalbumin content [1.8 g/(kg·d)]. Applying a non-linear mixed-effects model analysis of F13CO2, the protein requirement was determined by identifying the breakpoint in the F13CO2 data with graded amounts of dietary protein.ResultsThe mean estimated average requirement (EAR) and recommended nutrient intake (RNI) of protein for older adults with sarcopenia were 1.21 (95% CI: 0.95, 1.46) and 1.54 (95% CI: 1.13, 1.95) g/(kg·d), respectively.ConclusionsTo our knowledge, this is the first study of protein intake in older adults with sarcopenia and indicates that older adults with sarcopenia may require a higher intake of dietary protein.Clinical trial registrationhttp://www.chictr.org.cn, ChiCTR2200061383.https://www.frontiersin.org/articles/10.3389/fnut.2025.1486482/fullprotein requirementolder adultssarcopeniaindicator amino acid oxidationstable isotope |
| spellingShingle | Wenxuan Wu Fengge Chen Hui Ma Jiaxi Lu Jiaxi Lu Yanhong Zhang Haisong Zhou Yunqi Yang Shuhui Nie Rui Wang Rui Wang Weixiao Yue Min Li Min Li Xiaoguang Yang Xiaoguang Yang Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology Frontiers in Nutrition protein requirement older adults sarcopenia indicator amino acid oxidation stable isotope |
| title | Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology |
| title_full | Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology |
| title_fullStr | Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology |
| title_full_unstemmed | Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology |
| title_short | Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology |
| title_sort | dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology |
| topic | protein requirement older adults sarcopenia indicator amino acid oxidation stable isotope |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1486482/full |
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