Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities
Abstract Sea dragons (Syngnathus) are valuable marine resources with notable interspecific phenotypic similarities and variations in composition and efficacy. This study employed multi-omics technologies to comprehensively analyze and structurally identify the molecular components of six species of...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-025-00469-w |
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| author | Huixiang Wu Miaoyu Li Lijun Ge Weibo Lu Xuewei Shen Yu Zhang Zengyan Wu Jianding Wang Yonghui Wu Huijuan Mao Jianliang Zhang Qingcheng Wang Jing Xue Qing Shen Yuexing Tu |
| author_facet | Huixiang Wu Miaoyu Li Lijun Ge Weibo Lu Xuewei Shen Yu Zhang Zengyan Wu Jianding Wang Yonghui Wu Huijuan Mao Jianliang Zhang Qingcheng Wang Jing Xue Qing Shen Yuexing Tu |
| author_sort | Huixiang Wu |
| collection | DOAJ |
| description | Abstract Sea dragons (Syngnathus) are valuable marine resources with notable interspecific phenotypic similarities and variations in composition and efficacy. This study employed multi-omics technologies to comprehensively analyze and structurally identify the molecular components of six species of Syngnathus, effectively screening interspecific differential markers. Untargeted metabolomics revealed a total of 18 classes and 2264 metabolites, and lipids were found to be the principal differential metabolites. Lipidomics were utilized for in-depth lipid detection, expanding the original 412 lipids detected through metabolomics to 2078 lipids, among which 47 differential metabolites and 138 differential lipids were selected from multi-omics results. The integration of network pharmacology and molecular docking elucidated the multifactorial mechanisms by which Syngnathus exerts anti-sepsis effects, including modulation of inflammatory responses, and regulation of apoptosis, while identifying key targets such as IL6, STAT3, and MAPK14. This study suggests that they may have potential as natural sources for the development of anti-sepsis foods. Further studies on their bioavailability and in vitro and in vivo efficacy are required in the future. |
| format | Article |
| id | doaj-art-2668eb6745274efe86222972c4b1f1b3 |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-2668eb6745274efe86222972c4b1f1b32025-08-20T03:47:16ZengNature Portfolionpj Science of Food2396-83702025-06-019111210.1038/s41538-025-00469-wSea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activitiesHuixiang Wu0Miaoyu Li1Lijun Ge2Weibo Lu3Xuewei Shen4Yu Zhang5Zengyan Wu6Jianding Wang7Yonghui Wu8Huijuan Mao9Jianliang Zhang10Qingcheng Wang11Jing Xue12Qing Shen13Yuexing Tu14Collaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang UniversityCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang UniversityCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang UniversityCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang UniversityCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang UniversityCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang UniversityDepartment of Gastroenterology, Linping Hospital of Integrated Traditional Chinese and Western MedicineHangzhou Linping Hospital of Traditional Chinese MedicineHangzhou Linping Hospital of Traditional Chinese MedicineHangzhou Linping Hospital of Traditional Chinese MedicineHangzhou Linping Hospital of Traditional Chinese MedicineHangzhou Linping Hospital of Traditional Chinese MedicineCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang UniversityCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang UniversityDepartment of Critical Care Medicine, Tongde Hospital of Zhejiang Province, Tongde Hospital of Zhejiang Province Afflicted to Zhejiang Chinese Medical UniversityAbstract Sea dragons (Syngnathus) are valuable marine resources with notable interspecific phenotypic similarities and variations in composition and efficacy. This study employed multi-omics technologies to comprehensively analyze and structurally identify the molecular components of six species of Syngnathus, effectively screening interspecific differential markers. Untargeted metabolomics revealed a total of 18 classes and 2264 metabolites, and lipids were found to be the principal differential metabolites. Lipidomics were utilized for in-depth lipid detection, expanding the original 412 lipids detected through metabolomics to 2078 lipids, among which 47 differential metabolites and 138 differential lipids were selected from multi-omics results. The integration of network pharmacology and molecular docking elucidated the multifactorial mechanisms by which Syngnathus exerts anti-sepsis effects, including modulation of inflammatory responses, and regulation of apoptosis, while identifying key targets such as IL6, STAT3, and MAPK14. This study suggests that they may have potential as natural sources for the development of anti-sepsis foods. Further studies on their bioavailability and in vitro and in vivo efficacy are required in the future.https://doi.org/10.1038/s41538-025-00469-w |
| spellingShingle | Huixiang Wu Miaoyu Li Lijun Ge Weibo Lu Xuewei Shen Yu Zhang Zengyan Wu Jianding Wang Yonghui Wu Huijuan Mao Jianliang Zhang Qingcheng Wang Jing Xue Qing Shen Yuexing Tu Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities npj Science of Food |
| title | Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities |
| title_full | Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities |
| title_fullStr | Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities |
| title_full_unstemmed | Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities |
| title_short | Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities |
| title_sort | sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities |
| url | https://doi.org/10.1038/s41538-025-00469-w |
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