Otherwise Unexplained Transient QTc Prolongation in a Patient Admitted with COVID Disease
Background. Several cardiovascular manifestations of coronavirus disease 2019 (COVID-19) have been previously described. QT prolongation has been reported in COVID-19 infection in association with medications such as azithromycin, hydroxychloroquine, and chloroquine but has not previously been repor...
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Wiley
2021-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2021/9931405 |
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| author | Mark Coyle Mark Wilkinson Mark Sheehy |
| author_facet | Mark Coyle Mark Wilkinson Mark Sheehy |
| author_sort | Mark Coyle |
| collection | DOAJ |
| description | Background. Several cardiovascular manifestations of coronavirus disease 2019 (COVID-19) have been previously described. QT prolongation has been reported in COVID-19 infection in association with medications such as azithromycin, hydroxychloroquine, and chloroquine but has not previously been reported as a direct result of COVID-19 infection. Case summary. We report the case of a 65-year-old female who developed a prolonged corrected QT interval (QTc) during a hospital admission with COVID-19. This patient was not on any QT prolonging treatment, serum electrolytes were normal, and there was no identifiable reversible cause for the QTc lengthening. Daily serial ECGs during admission showed resolution of the ventricular repolarization abnormality in synchronization with resolution of her COVID-19 viral illness. Discussions. Although there have been reports of QTc prolongation in COVID-19 patients, previous reports of this are for patients receiving medication that causes QT prolongation. This case uniquely demonstrates the development and resolution of this temporary ventricular repolarization abnormality in a patient with a structurally normal heart with no evidence of myocardial fibrosis or edema on cardiac MRI, that is unexplained by other confounding factors, such as medication. This suggests there may be a direct association between COVID-19 and temporary QTc prolongation. |
| format | Article |
| id | doaj-art-26626e325aa4497ca0e539e5495b9d3d |
| institution | OA Journals |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-26626e325aa4497ca0e539e5495b9d3d2025-08-20T02:04:23ZengWileyCase Reports in Cardiology2090-64042090-64122021-01-01202110.1155/2021/99314059931405Otherwise Unexplained Transient QTc Prolongation in a Patient Admitted with COVID DiseaseMark Coyle0Mark Wilkinson1Mark Sheehy2Department of Medicine, Midlands Regional Hospital Mullingar, Longford Road, Robinstown, Mullingar, Westmeath, IrelandDepartment of Medicine, Midlands Regional Hospital Mullingar, Longford Road, Robinstown, Mullingar, Westmeath, IrelandDepartment of Medicine, Midlands Regional Hospital Mullingar, Longford Road, Robinstown, Mullingar, Westmeath, IrelandBackground. Several cardiovascular manifestations of coronavirus disease 2019 (COVID-19) have been previously described. QT prolongation has been reported in COVID-19 infection in association with medications such as azithromycin, hydroxychloroquine, and chloroquine but has not previously been reported as a direct result of COVID-19 infection. Case summary. We report the case of a 65-year-old female who developed a prolonged corrected QT interval (QTc) during a hospital admission with COVID-19. This patient was not on any QT prolonging treatment, serum electrolytes were normal, and there was no identifiable reversible cause for the QTc lengthening. Daily serial ECGs during admission showed resolution of the ventricular repolarization abnormality in synchronization with resolution of her COVID-19 viral illness. Discussions. Although there have been reports of QTc prolongation in COVID-19 patients, previous reports of this are for patients receiving medication that causes QT prolongation. This case uniquely demonstrates the development and resolution of this temporary ventricular repolarization abnormality in a patient with a structurally normal heart with no evidence of myocardial fibrosis or edema on cardiac MRI, that is unexplained by other confounding factors, such as medication. This suggests there may be a direct association between COVID-19 and temporary QTc prolongation.http://dx.doi.org/10.1155/2021/9931405 |
| spellingShingle | Mark Coyle Mark Wilkinson Mark Sheehy Otherwise Unexplained Transient QTc Prolongation in a Patient Admitted with COVID Disease Case Reports in Cardiology |
| title | Otherwise Unexplained Transient QTc Prolongation in a Patient Admitted with COVID Disease |
| title_full | Otherwise Unexplained Transient QTc Prolongation in a Patient Admitted with COVID Disease |
| title_fullStr | Otherwise Unexplained Transient QTc Prolongation in a Patient Admitted with COVID Disease |
| title_full_unstemmed | Otherwise Unexplained Transient QTc Prolongation in a Patient Admitted with COVID Disease |
| title_short | Otherwise Unexplained Transient QTc Prolongation in a Patient Admitted with COVID Disease |
| title_sort | otherwise unexplained transient qtc prolongation in a patient admitted with covid disease |
| url | http://dx.doi.org/10.1155/2021/9931405 |
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