Biosafety and efficacy evaluation of a biodegradable Zn-Cu-Mn stent: A long-term study in porcine coronary artery
In this study, biodegradable Zn-Cu-Mn alloy stents were implanted into porcine coronary artery for 18 months, and the in vivo biosafety and efficacy as well as the degradation behavior were systematically studied. Results showed a rapid endothelialization of the target vessel was achieved at 1 month...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24005061 |
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| author | Yi Qian Yan Chen Jimiao Jiang Jia Pei Junfei Li Jialin Niu Jinzhou Zhu Guangyin Yuan |
| author_facet | Yi Qian Yan Chen Jimiao Jiang Jia Pei Junfei Li Jialin Niu Jinzhou Zhu Guangyin Yuan |
| author_sort | Yi Qian |
| collection | DOAJ |
| description | In this study, biodegradable Zn-Cu-Mn alloy stents were implanted into porcine coronary artery for 18 months, and the in vivo biosafety and efficacy as well as the degradation behavior were systematically studied. Results showed a rapid endothelialization of the target vessel was achieved at 1 month post-implantation. Although the lumen diameter loss and local inflammation were observed at the early stage, the stented blood vessel could gradually recover with time. The lumen diameter was already close to normal range at 12 months, indicating good bioefficacy of the stent. No adverse effect on blood indexes or local accumulation of Zn, Cu or Mn elements were found after implantation, neither the malapposition and thrombosis were observed, which exhibited good biosafety of the stents. The stent could maintain the basic structure and mechanical integrity at 6 months, and remained only approximately 26 % of the stent volume at 18 months, suggesting a desirable degradation rate. In general, the Zn-Cu-Mn alloy stent showed great advantages and prospects in clinical application. |
| format | Article |
| id | doaj-art-2660ebea21d94873b40768cb74b3a6f7 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-2660ebea21d94873b40768cb74b3a6f72025-01-26T05:04:23ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-0145231245Biosafety and efficacy evaluation of a biodegradable Zn-Cu-Mn stent: A long-term study in porcine coronary arteryYi Qian0Yan Chen1Jimiao Jiang2Jia Pei3Junfei Li4Jialin Niu5Jinzhou Zhu6Guangyin Yuan7School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Department of Vascular & Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, ChinaSchool of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, ChinaSchool of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, ChinaSchool of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, ChinaShanghai MicroPort Medical (Group) Co., Ltd, Shanghai, 201203, ChinaSchool of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Corresponding author. National Engineering Research Center of Light Alloy Net Forming and Key State Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.Department of Vascular & Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Corresponding author. Department of Vascular & Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Corresponding author. National Engineering Research Center of Light Alloy Net Forming and Key State Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.In this study, biodegradable Zn-Cu-Mn alloy stents were implanted into porcine coronary artery for 18 months, and the in vivo biosafety and efficacy as well as the degradation behavior were systematically studied. Results showed a rapid endothelialization of the target vessel was achieved at 1 month post-implantation. Although the lumen diameter loss and local inflammation were observed at the early stage, the stented blood vessel could gradually recover with time. The lumen diameter was already close to normal range at 12 months, indicating good bioefficacy of the stent. No adverse effect on blood indexes or local accumulation of Zn, Cu or Mn elements were found after implantation, neither the malapposition and thrombosis were observed, which exhibited good biosafety of the stents. The stent could maintain the basic structure and mechanical integrity at 6 months, and remained only approximately 26 % of the stent volume at 18 months, suggesting a desirable degradation rate. In general, the Zn-Cu-Mn alloy stent showed great advantages and prospects in clinical application.http://www.sciencedirect.com/science/article/pii/S2452199X24005061Zn-Cu-Mn stentPorcine coronary arteryEfficacyBiosafetyDegradation behavior |
| spellingShingle | Yi Qian Yan Chen Jimiao Jiang Jia Pei Junfei Li Jialin Niu Jinzhou Zhu Guangyin Yuan Biosafety and efficacy evaluation of a biodegradable Zn-Cu-Mn stent: A long-term study in porcine coronary artery Bioactive Materials Zn-Cu-Mn stent Porcine coronary artery Efficacy Biosafety Degradation behavior |
| title | Biosafety and efficacy evaluation of a biodegradable Zn-Cu-Mn stent: A long-term study in porcine coronary artery |
| title_full | Biosafety and efficacy evaluation of a biodegradable Zn-Cu-Mn stent: A long-term study in porcine coronary artery |
| title_fullStr | Biosafety and efficacy evaluation of a biodegradable Zn-Cu-Mn stent: A long-term study in porcine coronary artery |
| title_full_unstemmed | Biosafety and efficacy evaluation of a biodegradable Zn-Cu-Mn stent: A long-term study in porcine coronary artery |
| title_short | Biosafety and efficacy evaluation of a biodegradable Zn-Cu-Mn stent: A long-term study in porcine coronary artery |
| title_sort | biosafety and efficacy evaluation of a biodegradable zn cu mn stent a long term study in porcine coronary artery |
| topic | Zn-Cu-Mn stent Porcine coronary artery Efficacy Biosafety Degradation behavior |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24005061 |
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