Nanoparticles and Inflammation
The development of nanoscale molecular probes capable of diagnosis, characterization, and clinical treatment of disease is leading to a new generation of imaging technologies. Such probes are particularly relevant to inflammation, where the detection of subclinical, early disease states could facili...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2011.106 |
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| _version_ | 1832566742115680256 |
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| author | Ross Stevenson Axel J. Hueber Alan Hutton Iain B. McInnes Duncan Graham |
| author_facet | Ross Stevenson Axel J. Hueber Alan Hutton Iain B. McInnes Duncan Graham |
| author_sort | Ross Stevenson |
| collection | DOAJ |
| description | The development of nanoscale molecular probes capable of diagnosis, characterization, and clinical treatment of disease is leading to a new generation of imaging technologies. Such probes are particularly relevant to inflammation, where the detection of subclinical, early disease states could facilitate speedier detection that could yield enhanced, tailored therapies. Nanoparticles offer robust platforms capable of sensitive detection, and early research has indicated their suitability for the detection of vascular activation and cellular recruitment at subclinical levels. This suggests that nanoparticle techniques may provide excellent biomarkers for the diagnosis and progression of inflammatory diseases with magnetic resonance imaging (MRI), fluorescent quantum dots (QDs), and surface enhanced Raman scattering (SERS) probes being just some of the new methodologies employed. Development of these techniques could lead to a range of sensitive probes capable of ultrasensitive, localized detection of inflammation. This article will discuss the merits of each approach, with a general overview to their applicability in inflammatory diseases. |
| format | Article |
| id | doaj-art-265c752474c441a693ec212b189916ff |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-265c752474c441a693ec212b189916ff2025-02-03T01:03:15ZengWileyThe Scientific World Journal1537-744X2011-01-01111300131210.1100/tsw.2011.106Nanoparticles and InflammationRoss Stevenson0Axel J. Hueber1Alan Hutton2Iain B. McInnes3Duncan Graham4Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Glasgow, UKCentre for Rheumatic Diseases, University of Glasgow, Glasgow, UKCentre for Molecular Nanometrology, Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Glasgow, UKCentre for Rheumatic Diseases, University of Glasgow, Glasgow, UKCentre for Molecular Nanometrology, Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Glasgow, UKThe development of nanoscale molecular probes capable of diagnosis, characterization, and clinical treatment of disease is leading to a new generation of imaging technologies. Such probes are particularly relevant to inflammation, where the detection of subclinical, early disease states could facilitate speedier detection that could yield enhanced, tailored therapies. Nanoparticles offer robust platforms capable of sensitive detection, and early research has indicated their suitability for the detection of vascular activation and cellular recruitment at subclinical levels. This suggests that nanoparticle techniques may provide excellent biomarkers for the diagnosis and progression of inflammatory diseases with magnetic resonance imaging (MRI), fluorescent quantum dots (QDs), and surface enhanced Raman scattering (SERS) probes being just some of the new methodologies employed. Development of these techniques could lead to a range of sensitive probes capable of ultrasensitive, localized detection of inflammation. This article will discuss the merits of each approach, with a general overview to their applicability in inflammatory diseases.http://dx.doi.org/10.1100/tsw.2011.106 |
| spellingShingle | Ross Stevenson Axel J. Hueber Alan Hutton Iain B. McInnes Duncan Graham Nanoparticles and Inflammation The Scientific World Journal |
| title | Nanoparticles and Inflammation |
| title_full | Nanoparticles and Inflammation |
| title_fullStr | Nanoparticles and Inflammation |
| title_full_unstemmed | Nanoparticles and Inflammation |
| title_short | Nanoparticles and Inflammation |
| title_sort | nanoparticles and inflammation |
| url | http://dx.doi.org/10.1100/tsw.2011.106 |
| work_keys_str_mv | AT rossstevenson nanoparticlesandinflammation AT axeljhueber nanoparticlesandinflammation AT alanhutton nanoparticlesandinflammation AT iainbmcinnes nanoparticlesandinflammation AT duncangraham nanoparticlesandinflammation |