Navigating transfusion challenges: Bombay blood group in focus
“Bombay” and “Para-Bombay” phenotypes are uncommon blood groups with absence or deficiency of H antigen. These individuals possess anti-H antibodies and crossmatching with ABO blood group packed red blood cells (PRBC) becomes incompatible. In this report, we find out alternative strategy (patient bl...
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Education and Health Promotion |
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| Online Access: | https://journals.lww.com/10.4103/jehp.jehp_519_24 |
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| author | Romesh Jain Vilasini Patil Pratul Sinha Snehashish Mishra Rut Naik |
| author_facet | Romesh Jain Vilasini Patil Pratul Sinha Snehashish Mishra Rut Naik |
| author_sort | Romesh Jain |
| collection | DOAJ |
| description | “Bombay” and “Para-Bombay” phenotypes are uncommon blood groups with absence or deficiency of H antigen. These individuals possess anti-H antibodies and crossmatching with ABO blood group packed red blood cells (PRBC) becomes incompatible. In this report, we find out alternative strategy (patient blood management) for the management of anemia in Bombay blood group patient. Case: A 49-year-old woman referred to our hospital with severe anemia (Hb = 6 gm/dl). On history patient visited to peripheral hospital with complains of fatigue and weakness. Patient was transfused one unit of group O PRBC and suffered hemolytic transfusion reaction. At our center, blood group analysis was performed by the standard tube technique. In the forward group, there was negative reaction with anti-A, anti-B, and anti-AB sera, and 4+ reaction was showing with anti-D sera. In reverse grouping, there was 4 + reaction with A cell, B cell, and O cell and negative reaction with autocontrol. This suggests that patient was having a strong antibody other than anti-A and anti-B, which was reacting strongly with O cell at all temperatures. Anti-H lectin reaction was negative. The patient was diagnosed with probable Bombay phenotype (hh), and we tried to manage anemia with patient blood management. Patient was started on oral iron supplementation, and after 2 month of treatment, the patient had Hb of 13.3 gm/dl with no complains of fatigue and weakness. In this report, we reiterate the importance of patient blood management and would also like to emphasize to implement the rare group registry in India. |
| format | Article |
| id | doaj-art-265855a3dc6d491995dd94c583c0fb66 |
| institution | Kabale University |
| issn | 2277-9531 2319-6440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Education and Health Promotion |
| spelling | doaj-art-265855a3dc6d491995dd94c583c0fb662025-02-06T09:49:50ZengWolters Kluwer Medknow PublicationsJournal of Education and Health Promotion2277-95312319-64402025-01-01141191910.4103/jehp.jehp_519_24Navigating transfusion challenges: Bombay blood group in focusRomesh JainVilasini PatilPratul SinhaSnehashish MishraRut Naik“Bombay” and “Para-Bombay” phenotypes are uncommon blood groups with absence or deficiency of H antigen. These individuals possess anti-H antibodies and crossmatching with ABO blood group packed red blood cells (PRBC) becomes incompatible. In this report, we find out alternative strategy (patient blood management) for the management of anemia in Bombay blood group patient. Case: A 49-year-old woman referred to our hospital with severe anemia (Hb = 6 gm/dl). On history patient visited to peripheral hospital with complains of fatigue and weakness. Patient was transfused one unit of group O PRBC and suffered hemolytic transfusion reaction. At our center, blood group analysis was performed by the standard tube technique. In the forward group, there was negative reaction with anti-A, anti-B, and anti-AB sera, and 4+ reaction was showing with anti-D sera. In reverse grouping, there was 4 + reaction with A cell, B cell, and O cell and negative reaction with autocontrol. This suggests that patient was having a strong antibody other than anti-A and anti-B, which was reacting strongly with O cell at all temperatures. Anti-H lectin reaction was negative. The patient was diagnosed with probable Bombay phenotype (hh), and we tried to manage anemia with patient blood management. Patient was started on oral iron supplementation, and after 2 month of treatment, the patient had Hb of 13.3 gm/dl with no complains of fatigue and weakness. In this report, we reiterate the importance of patient blood management and would also like to emphasize to implement the rare group registry in India.https://journals.lww.com/10.4103/jehp.jehp_519_24bombay phenotypeiron deficiency anemiapatient blood managementrare blood group registry |
| spellingShingle | Romesh Jain Vilasini Patil Pratul Sinha Snehashish Mishra Rut Naik Navigating transfusion challenges: Bombay blood group in focus Journal of Education and Health Promotion bombay phenotype iron deficiency anemia patient blood management rare blood group registry |
| title | Navigating transfusion challenges: Bombay blood group in focus |
| title_full | Navigating transfusion challenges: Bombay blood group in focus |
| title_fullStr | Navigating transfusion challenges: Bombay blood group in focus |
| title_full_unstemmed | Navigating transfusion challenges: Bombay blood group in focus |
| title_short | Navigating transfusion challenges: Bombay blood group in focus |
| title_sort | navigating transfusion challenges bombay blood group in focus |
| topic | bombay phenotype iron deficiency anemia patient blood management rare blood group registry |
| url | https://journals.lww.com/10.4103/jehp.jehp_519_24 |
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