Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization
In this work, a new approach was introduced to prepare interpenetrating polymer network PVA/GE hydrogels by cross-linking of various concentration gelatin in the presence of transglutaminase enzyme by using the freezing-thawing cycles technique. The effects of freezing-thawing cycles on the properti...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2013/328763 |
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| _version_ | 1850228943700885504 |
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| author | Eltjani-Eltahir Hago Xinsong Li |
| author_facet | Eltjani-Eltahir Hago Xinsong Li |
| author_sort | Eltjani-Eltahir Hago |
| collection | DOAJ |
| description | In this work, a new approach was introduced to prepare interpenetrating polymer network PVA/GE hydrogels by cross-linking of various concentration gelatin in the presence of transglutaminase enzyme by using the freezing-thawing cycles technique. The effects of freezing-thawing cycles on the properties of morphological characterization, gel fraction, swelling, mechanical, and MTT assay were investigated. The IPN PVA/GE hydrogels showed excellent physical and mechanical Properties. MTT assay data and the fibroblasts culture also showed excellent biocompatibility and good proliferation. This indicates that the IPN hydrogels are stable enough for various biomedical applications. |
| format | Article |
| id | doaj-art-2653fb41822e455e81a4fbfb230a7a6a |
| institution | OA Journals |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-2653fb41822e455e81a4fbfb230a7a6a2025-08-20T02:04:23ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422013-01-01201310.1155/2013/328763328763Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and CharacterizationEltjani-Eltahir Hago0Xinsong Li1Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, ChinaSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, ChinaIn this work, a new approach was introduced to prepare interpenetrating polymer network PVA/GE hydrogels by cross-linking of various concentration gelatin in the presence of transglutaminase enzyme by using the freezing-thawing cycles technique. The effects of freezing-thawing cycles on the properties of morphological characterization, gel fraction, swelling, mechanical, and MTT assay were investigated. The IPN PVA/GE hydrogels showed excellent physical and mechanical Properties. MTT assay data and the fibroblasts culture also showed excellent biocompatibility and good proliferation. This indicates that the IPN hydrogels are stable enough for various biomedical applications.http://dx.doi.org/10.1155/2013/328763 |
| spellingShingle | Eltjani-Eltahir Hago Xinsong Li Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization Advances in Materials Science and Engineering |
| title | Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization |
| title_full | Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization |
| title_fullStr | Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization |
| title_full_unstemmed | Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization |
| title_short | Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization |
| title_sort | interpenetrating polymer network hydrogels based on gelatin and pva by biocompatible approaches synthesis and characterization |
| url | http://dx.doi.org/10.1155/2013/328763 |
| work_keys_str_mv | AT eltjanieltahirhago interpenetratingpolymernetworkhydrogelsbasedongelatinandpvabybiocompatibleapproachessynthesisandcharacterization AT xinsongli interpenetratingpolymernetworkhydrogelsbasedongelatinandpvabybiocompatibleapproachessynthesisandcharacterization |