Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing.
<h4>Background</h4>Subjects born preterm have an increased risk for age-associated diseases, such as cardiovascular disease in later life, but the underlying causes are largely unknown. Shorter leukocyte telomere length (LTL), a marker of biological age, is associated with increased risk...
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Public Library of Science (PLoS)
2015-01-01
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| author | Carolina C J Smeets Veryan Codd Nilesh J Samani Anita C S Hokken-Koelega |
| author_facet | Carolina C J Smeets Veryan Codd Nilesh J Samani Anita C S Hokken-Koelega |
| author_sort | Carolina C J Smeets |
| collection | DOAJ |
| description | <h4>Background</h4>Subjects born preterm have an increased risk for age-associated diseases, such as cardiovascular disease in later life, but the underlying causes are largely unknown. Shorter leukocyte telomere length (LTL), a marker of biological age, is associated with increased risk of cardiovascular disease.<h4>Objectives</h4>To compare LTL between subjects born preterm and at term and to assess if LTL is associated with other putative cardiovascular risk factors at young adult age.<h4>Methods</h4>We measured mean LTL in 470 young adults. LTL was measured using a quantitative PCR assay and expressed as T/S ratio. We analyzed the influence of gestational age on LTL and compared LTL between subjects born preterm (n = 186) and at term (n = 284). Additionally, we analyzed the correlation between LTL and potential risk factors of cardiovascular disease.<h4>Results</h4>Gestational age was positively associated with LTL (r = 0.11, p = 0.02). Subjects born preterm had shorter LTL (mean (SD) T/S ratio = 3.12 (0.44)) than subjects born at term (mean (SD) T/S ratio = 3.25 (0.46)), p = 0.003). The difference remained significant after adjustment for gender and size at birth (p = 0.001). There was no association of LTL with any one of the putative risk factors analyzed.<h4>Conclusions</h4>Young adults born preterm have shorter LTL than young adults born at term. Although we found no correlation between LTL and risk for CVD at this young adult age, this biological ageing indicator may contribute to CVD and other adult onset diseases at a later age in those born preterm. |
| format | Article |
| id | doaj-art-264a662a0aec4af8b32d30ef7f3df573 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-264a662a0aec4af8b32d30ef7f3df5732025-08-20T03:46:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014395110.1371/journal.pone.0143951Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing.Carolina C J SmeetsVeryan CoddNilesh J SamaniAnita C S Hokken-Koelega<h4>Background</h4>Subjects born preterm have an increased risk for age-associated diseases, such as cardiovascular disease in later life, but the underlying causes are largely unknown. Shorter leukocyte telomere length (LTL), a marker of biological age, is associated with increased risk of cardiovascular disease.<h4>Objectives</h4>To compare LTL between subjects born preterm and at term and to assess if LTL is associated with other putative cardiovascular risk factors at young adult age.<h4>Methods</h4>We measured mean LTL in 470 young adults. LTL was measured using a quantitative PCR assay and expressed as T/S ratio. We analyzed the influence of gestational age on LTL and compared LTL between subjects born preterm (n = 186) and at term (n = 284). Additionally, we analyzed the correlation between LTL and potential risk factors of cardiovascular disease.<h4>Results</h4>Gestational age was positively associated with LTL (r = 0.11, p = 0.02). Subjects born preterm had shorter LTL (mean (SD) T/S ratio = 3.12 (0.44)) than subjects born at term (mean (SD) T/S ratio = 3.25 (0.46)), p = 0.003). The difference remained significant after adjustment for gender and size at birth (p = 0.001). There was no association of LTL with any one of the putative risk factors analyzed.<h4>Conclusions</h4>Young adults born preterm have shorter LTL than young adults born at term. Although we found no correlation between LTL and risk for CVD at this young adult age, this biological ageing indicator may contribute to CVD and other adult onset diseases at a later age in those born preterm.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143951&type=printable |
| spellingShingle | Carolina C J Smeets Veryan Codd Nilesh J Samani Anita C S Hokken-Koelega Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing. PLoS ONE |
| title | Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing. |
| title_full | Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing. |
| title_fullStr | Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing. |
| title_full_unstemmed | Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing. |
| title_short | Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing. |
| title_sort | leukocyte telomere length in young adults born preterm support for accelerated biological ageing |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0143951&type=printable |
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