Protective effect of the Prunella grandiflora L. extract in relation to the toxic effect of etoposide through the example of Drosophila melanogaster
The data on the protective properties of the Prunella grandiflora L. extract were obtained when used together with the anticancer drug etoposide on the experimental strain of Drosophila melanogaster. The combined use of etoposide and 10% extract of P. grandiflora decreased mortality in D. melanogas...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2021-07-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/4371 |
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| author | O. N. Antosyuk E. V. Bolotnik A. S. Postovalova |
| author_facet | O. N. Antosyuk E. V. Bolotnik A. S. Postovalova |
| author_sort | O. N. Antosyuk |
| collection | DOAJ |
| description | The data on the protective properties of the Prunella grandiflora L. extract were obtained when used together with the anticancer drug etoposide on the experimental strain of Drosophila melanogaster. The combined use of etoposide and 10% extract of P. grandiflora decreased mortality in D. melanogaster individuals to 15% and doubled the average individual fertility compared to the use of this cytostatic drug without the extract. Using the SMART method, the presence of the antigenotoxic effect was identified, which manifests itself through the absence of chromosomal aberrations. |
| format | Article |
| id | doaj-art-2648ada6b1eb4e92a28e24fbd191fd48 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-2648ada6b1eb4e92a28e24fbd191fd482025-08-20T03:38:06ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842021-07-0120261110.20538/1682-0363-2021-2-6-112774Protective effect of the Prunella grandiflora L. extract in relation to the toxic effect of etoposide through the example of Drosophila melanogasterO. N. Antosyuk0E. V. Bolotnik1A. S. Postovalova2Ural Federal University (UrFU) named after the first President of Russia B.N. YeltsinBotanical Garden of the Ural Branch of the Russian Academy of SciencesUral Federal University (UrFU) named after the first President of Russia B.N. YeltsinThe data on the protective properties of the Prunella grandiflora L. extract were obtained when used together with the anticancer drug etoposide on the experimental strain of Drosophila melanogaster. The combined use of etoposide and 10% extract of P. grandiflora decreased mortality in D. melanogaster individuals to 15% and doubled the average individual fertility compared to the use of this cytostatic drug without the extract. Using the SMART method, the presence of the antigenotoxic effect was identified, which manifests itself through the absence of chromosomal aberrations.https://bulletin.ssmu.ru/jour/article/view/4371medicinal plantsantigenotoxic effectdrosophila melanogasterprotective propertiesetoposidesmart |
| spellingShingle | O. N. Antosyuk E. V. Bolotnik A. S. Postovalova Protective effect of the Prunella grandiflora L. extract in relation to the toxic effect of etoposide through the example of Drosophila melanogaster Бюллетень сибирской медицины medicinal plants antigenotoxic effect drosophila melanogaster protective properties etoposide smart |
| title | Protective effect of the Prunella grandiflora L. extract in relation to the toxic effect of etoposide through the example of Drosophila melanogaster |
| title_full | Protective effect of the Prunella grandiflora L. extract in relation to the toxic effect of etoposide through the example of Drosophila melanogaster |
| title_fullStr | Protective effect of the Prunella grandiflora L. extract in relation to the toxic effect of etoposide through the example of Drosophila melanogaster |
| title_full_unstemmed | Protective effect of the Prunella grandiflora L. extract in relation to the toxic effect of etoposide through the example of Drosophila melanogaster |
| title_short | Protective effect of the Prunella grandiflora L. extract in relation to the toxic effect of etoposide through the example of Drosophila melanogaster |
| title_sort | protective effect of the prunella grandiflora l extract in relation to the toxic effect of etoposide through the example of drosophila melanogaster |
| topic | medicinal plants antigenotoxic effect drosophila melanogaster protective properties etoposide smart |
| url | https://bulletin.ssmu.ru/jour/article/view/4371 |
| work_keys_str_mv | AT onantosyuk protectiveeffectoftheprunellagrandifloralextractinrelationtothetoxiceffectofetoposidethroughtheexampleofdrosophilamelanogaster AT evbolotnik protectiveeffectoftheprunellagrandifloralextractinrelationtothetoxiceffectofetoposidethroughtheexampleofdrosophilamelanogaster AT aspostovalova protectiveeffectoftheprunellagrandifloralextractinrelationtothetoxiceffectofetoposidethroughtheexampleofdrosophilamelanogaster |