Neutrophil Reverse Migration Becomes Transparent with Zebrafish
The precise control of neutrophil-mediated inflammation is critical for both host defense and the prevention of immunopathology. In vivo imaging studies in zebrafish, and more recently in mice, have made the novel observation that neutrophils leave a site of inflammation through a process called neu...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/398640 |
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| _version_ | 1832563134295965696 |
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| author | Taylor W. Starnes Anna Huttenlocher |
| author_facet | Taylor W. Starnes Anna Huttenlocher |
| author_sort | Taylor W. Starnes |
| collection | DOAJ |
| description | The precise control of neutrophil-mediated inflammation is critical for both host defense and the prevention of immunopathology. In vivo imaging studies in zebrafish, and more recently in mice, have made the novel observation that neutrophils leave a site of inflammation through a process called neutrophil reverse migration. The application of advanced imaging techniques to the genetically tractable, optically transparent zebrafish larvae was critical for these advances. Still, the mechanisms underlying neutrophil reverse migration and its effects on the resolution or priming of immune responses remain unclear. Here, we review the current knowledge of neutrophil reverse migration, its potential roles in host immunity, and the live imaging tools that make zebrafish a valuable model for increasing our knowledge of neutrophil behavior in vivo. |
| format | Article |
| id | doaj-art-264584c83de6415ea6de9de80014d465 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-264584c83de6415ea6de9de80014d4652025-02-03T01:20:47ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/398640398640Neutrophil Reverse Migration Becomes Transparent with ZebrafishTaylor W. Starnes0Anna Huttenlocher1Microbiology Doctoral Training Program and Medical Scientist Training Program, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Pediatrics and Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USAThe precise control of neutrophil-mediated inflammation is critical for both host defense and the prevention of immunopathology. In vivo imaging studies in zebrafish, and more recently in mice, have made the novel observation that neutrophils leave a site of inflammation through a process called neutrophil reverse migration. The application of advanced imaging techniques to the genetically tractable, optically transparent zebrafish larvae was critical for these advances. Still, the mechanisms underlying neutrophil reverse migration and its effects on the resolution or priming of immune responses remain unclear. Here, we review the current knowledge of neutrophil reverse migration, its potential roles in host immunity, and the live imaging tools that make zebrafish a valuable model for increasing our knowledge of neutrophil behavior in vivo.http://dx.doi.org/10.1155/2012/398640 |
| spellingShingle | Taylor W. Starnes Anna Huttenlocher Neutrophil Reverse Migration Becomes Transparent with Zebrafish Advances in Hematology |
| title | Neutrophil Reverse Migration Becomes Transparent with Zebrafish |
| title_full | Neutrophil Reverse Migration Becomes Transparent with Zebrafish |
| title_fullStr | Neutrophil Reverse Migration Becomes Transparent with Zebrafish |
| title_full_unstemmed | Neutrophil Reverse Migration Becomes Transparent with Zebrafish |
| title_short | Neutrophil Reverse Migration Becomes Transparent with Zebrafish |
| title_sort | neutrophil reverse migration becomes transparent with zebrafish |
| url | http://dx.doi.org/10.1155/2012/398640 |
| work_keys_str_mv | AT taylorwstarnes neutrophilreversemigrationbecomestransparentwithzebrafish AT annahuttenlocher neutrophilreversemigrationbecomestransparentwithzebrafish |