Photodynamic therapy for precancer diseases and cervical cancer (review of literature)
The paper presents the results of literature data analysis on the main directions of precancerous diseases of the cervix uteri and cervical cancer treatment. Side effects following surgery or radiation treatment can lead to structural deformities, scarring, hyperpigmentation, systemic side effects,...
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2022-02-01
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| Series: | Biomedical Photonics |
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| Online Access: | https://www.pdt-journal.com/jour/article/view/519 |
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| author | A. V. Gilyadova Yu. S. Romanko A. A. Ishchenko S. V. Samoilova A. A. Shiryaev P. M. Alekseeva K. T. Efendiev I. V. Reshetov |
| author_facet | A. V. Gilyadova Yu. S. Romanko A. A. Ishchenko S. V. Samoilova A. A. Shiryaev P. M. Alekseeva K. T. Efendiev I. V. Reshetov |
| author_sort | A. V. Gilyadova |
| collection | DOAJ |
| description | The paper presents the results of literature data analysis on the main directions of precancerous diseases of the cervix uteri and cervical cancer treatment. Side effects following surgery or radiation treatment can lead to structural deformities, scarring, hyperpigmentation, systemic side effects, and destruction of normal tissue. In addition, the use of traditional methods of treatment can cause multidrug resistance, which will lead to ineffective treatment and the development of a relapse of the disease. To avoid toxicity and reduce side effects, alternative treatment strategies have been proposed. Photodynamic therapy (PDT) is a promising organ-preserving highly selective method for treating cervical neoplasia, which includes two stages: the introduction of a photosensitizer and local exposure to directed light radiation. A number of studies have demonstrated the high clinical efficacy of this method in the treatment of patients with cervical neoplasia and carriage of human papillomavirus infection without adverse consequences for fertility. The use of PDT contributes to the successful outcome of the treatment of pathological foci on the mucous membrane of the cervix, the effectiveness and safety of the method is ensured by the selective effect on tissues. In the course of treatment, normal surrounding tissues are not damaged, there is no gross scarring and stenosis of the cervical canal, thereby PDT allows maintaining the normal anatomical and functional characteristics of the cervix. |
| format | Article |
| id | doaj-art-2645337430f94587a7d9cbb58d067cc2 |
| institution | DOAJ |
| issn | 2413-9432 |
| language | Russian |
| publishDate | 2022-02-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj-art-2645337430f94587a7d9cbb58d067cc22025-08-20T03:21:05ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322022-02-01104596710.24931/2413-9432-2021-10-4-59-67244Photodynamic therapy for precancer diseases and cervical cancer (review of literature)A. V. Gilyadova0Yu. S. Romanko1A. A. Ishchenko2S. V. Samoilova3A. A. Shiryaev4P. M. Alekseeva5K. T. Efendiev6I. V. Reshetov7Sechenov First Moscow State Medical University; Treatment and Rehabilitation CenterSechenov First Moscow State Medical UniversityTreatment and Rehabilitation CenterSechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversityProkhorov General Physics Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Prokhorov General Physics Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Sechenov First Moscow State Medical University; Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia; Moscow Witte UniversityThe paper presents the results of literature data analysis on the main directions of precancerous diseases of the cervix uteri and cervical cancer treatment. Side effects following surgery or radiation treatment can lead to structural deformities, scarring, hyperpigmentation, systemic side effects, and destruction of normal tissue. In addition, the use of traditional methods of treatment can cause multidrug resistance, which will lead to ineffective treatment and the development of a relapse of the disease. To avoid toxicity and reduce side effects, alternative treatment strategies have been proposed. Photodynamic therapy (PDT) is a promising organ-preserving highly selective method for treating cervical neoplasia, which includes two stages: the introduction of a photosensitizer and local exposure to directed light radiation. A number of studies have demonstrated the high clinical efficacy of this method in the treatment of patients with cervical neoplasia and carriage of human papillomavirus infection without adverse consequences for fertility. The use of PDT contributes to the successful outcome of the treatment of pathological foci on the mucous membrane of the cervix, the effectiveness and safety of the method is ensured by the selective effect on tissues. In the course of treatment, normal surrounding tissues are not damaged, there is no gross scarring and stenosis of the cervical canal, thereby PDT allows maintaining the normal anatomical and functional characteristics of the cervix.https://www.pdt-journal.com/jour/article/view/519cervical cancercervical dysplasiahuman papillomavirusphotodynamic therapyphotosensitizers |
| spellingShingle | A. V. Gilyadova Yu. S. Romanko A. A. Ishchenko S. V. Samoilova A. A. Shiryaev P. M. Alekseeva K. T. Efendiev I. V. Reshetov Photodynamic therapy for precancer diseases and cervical cancer (review of literature) Biomedical Photonics cervical cancer cervical dysplasia human papillomavirus photodynamic therapy photosensitizers |
| title | Photodynamic therapy for precancer diseases and cervical cancer (review of literature) |
| title_full | Photodynamic therapy for precancer diseases and cervical cancer (review of literature) |
| title_fullStr | Photodynamic therapy for precancer diseases and cervical cancer (review of literature) |
| title_full_unstemmed | Photodynamic therapy for precancer diseases and cervical cancer (review of literature) |
| title_short | Photodynamic therapy for precancer diseases and cervical cancer (review of literature) |
| title_sort | photodynamic therapy for precancer diseases and cervical cancer review of literature |
| topic | cervical cancer cervical dysplasia human papillomavirus photodynamic therapy photosensitizers |
| url | https://www.pdt-journal.com/jour/article/view/519 |
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