IGF-1R promotes pain-like behavior in rats with myofascial pain syndrome via the PI3K/AKT pathway

IGF-1R promotes pain-like behavior in rats with myofascial pain syndrome via the PI3K/AKT pathway

Abstract Myofascial pain syndrome (MPS) is a common chronic pain condition characterized primarily by the presence of myofascial trigger points (MTrPs). While the insulin-like growth factor-1 receptor (IGF-1R) is known to be upregulated in injured muscles and implicated in orofacial neuropathic pain...

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Bibliographic Details
Main Authors: Lingwei Zhou, Miao Pei, Tian Qi, Yu Liu, Xiaoyue Li, Xuan Li, Qinghe Chen, Feihong Jin, Shaozhong Yang, Feng Qi
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-12552-z
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