MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques.

MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques.

<h4>Background</h4>Continuous high global tuberculosis (TB) mortality rates and variable vaccine efficacy of Mycobacterium bovis Bacille Calmette-Guérin (BCG) motivate the search for better vaccine regimes. Relevant models are required to downselect the most promising vaccines entering c...

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Main Authors: Frank A W Verreck, Richard A W Vervenne, Ivanela Kondova, Klaas W van Kralingen, Edmond J Remarque, Gerco Braskamp, Nicole M van der Werff, Ariena Kersbergen, Tom H M Ottenhoff, Peter J Heidt, Sarah C Gilbert, Brigitte Gicquel, Adrian V S Hill, Carlos Martin, Helen McShane, Alan W Thomas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005264&type=printable
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