Single spike mutation differentiating XBB.1 and XBB.1.5 enhances SARS-CoV-2 cell-to-cell transmission and facilitates serum-mediated enhancement

Single spike mutation differentiating XBB.1 and XBB.1.5 enhances SARS-CoV-2 cell-to-cell transmission and facilitates serum-mediated enhancement

IntroductionThe ongoing emergence of SARS-CoV-2 variants poses significant challenges to existing therapeutics. The spike (S) glycoprotein is central to both viral entry and cell-to-cell transmission via syncytia formation, a process that confers resistance to neutralizing antibodies. The mechanisms...

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Bibliographic Details
Main Authors: Elena Criscuolo, Benedetta Giuliani, Matteo Castelli, Mattia Cavallaro, Sofia Sisti, Roberto Burioni, Davide Ferrari, Nicasio Mancini, Massimo Locatelli, Nicola Clementi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
Spike
COVID-19
XBB.1
XBB.1.5
neutralizing antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501200/full
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