Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis
Abstract Background The COVID-19 pandemic has significantly impacted public health, with emerging evidence suggesting substantial effects on maternal and neonatal health. This systematic review and meta-analysis aimed to quantify the prevalence and risk of respiratory distress syndrome (RDS) in newb...
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2024-11-01
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| Online Access: | https://doi.org/10.1186/s12879-024-10161-1 |
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| author | Muhammed Shabil Shilpa Gaidhane Suhas Ballal Sanjay Kumar Mahakshit Bhat Shilpa Sharma M Ravi Kumar Sarvesh Rustagi Mahalaqua Nazli Khatib Nishant Rai Mohammed Garout Nabiha A. Bouafia Amer Alshengeti Hayam A Alrasheed Nawal A. Al Kaabi Mubarak Alfaresi Ali Hazazi Ali A. Rabaan Sanjit Sah Sorabh Lakhanpal Ganesh Bushi Laksmi Thangavelu Nagavalli Chilakam Sakshi Pandey Manvinder Brar Rachana Mehta Ashok Kumar Balaraman Rukshar Syed Gajendra Sharma |
| author_facet | Muhammed Shabil Shilpa Gaidhane Suhas Ballal Sanjay Kumar Mahakshit Bhat Shilpa Sharma M Ravi Kumar Sarvesh Rustagi Mahalaqua Nazli Khatib Nishant Rai Mohammed Garout Nabiha A. Bouafia Amer Alshengeti Hayam A Alrasheed Nawal A. Al Kaabi Mubarak Alfaresi Ali Hazazi Ali A. Rabaan Sanjit Sah Sorabh Lakhanpal Ganesh Bushi Laksmi Thangavelu Nagavalli Chilakam Sakshi Pandey Manvinder Brar Rachana Mehta Ashok Kumar Balaraman Rukshar Syed Gajendra Sharma |
| author_sort | Muhammed Shabil |
| collection | DOAJ |
| description | Abstract Background The COVID-19 pandemic has significantly impacted public health, with emerging evidence suggesting substantial effects on maternal and neonatal health. This systematic review and meta-analysis aimed to quantify the prevalence and risk of respiratory distress syndrome (RDS) in newborns born to mothers infected with SARS-CoV-2, the virus responsible for COVID-19. Methods We conducted a literature search in Embase, PubMed, and Web of Science up to April 20, without language or date restrictions. Observational studies reporting on the prevalence or risk of RDS among newborns from mothers with confirmed SARS-CoV-2 infection were included. Quality assessment was performed using the JBI tool. Statistical analysis was performed by using R software version 4.3. Results Twenty-two studies met the inclusion criteria. The pooled prevalence of RDS among newborns born to COVID-19-infected mothers was 11.5% (95% CI: 7.4–17.3%), with significant heterogeneity (I² = 93%). Newborns from infected mothers had a significantly higher risk of developing RDS, with a pooled risk ratio (RR) of 2.69 (95% CI: 1.77 to 4.17). Conclusion Newborns born to mothers with COVID-19 have a substantially increased risk of developing RDS. These findings emphasize the need for vigilant monitoring and appropriate management of pregnant women with COVID-19 to mitigate adverse neonatal outcomes. |
| format | Article |
| id | doaj-art-262fdea4bff34680a062ddaaae32b561 |
| institution | OA Journals |
| issn | 1471-2334 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-262fdea4bff34680a062ddaaae32b5612025-08-20T02:32:55ZengBMCBMC Infectious Diseases1471-23342024-11-0124111310.1186/s12879-024-10161-1Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysisMuhammed Shabil0Shilpa Gaidhane1Suhas Ballal2Sanjay Kumar3Mahakshit Bhat4Shilpa Sharma5M Ravi Kumar6Sarvesh Rustagi7Mahalaqua Nazli Khatib8Nishant Rai9Mohammed Garout10Nabiha A. Bouafia11Amer Alshengeti12Hayam A Alrasheed13Nawal A. Al Kaabi14Mubarak Alfaresi15Ali Hazazi16Ali A. Rabaan17Sanjit Sah18Sorabh Lakhanpal19Ganesh Bushi20Laksmi Thangavelu21Nagavalli Chilakam22Sakshi Pandey23Manvinder Brar24Rachana Mehta25Ashok Kumar Balaraman26Rukshar Syed27Gajendra Sharma28University Center for Research and Development, Chandigarh UniversityOne Health Centre, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher EducationDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University)Department of Allied Healthcare and Sciences, Vivekananda Global UniversityDepartment of Medicine, National Institute of Medical Sciences, NIMS University RajasthanChandigarh Pharmacy College, Chandigarh Group of Colleges-JhanjeriDepartment of Chemistry, Raghu Engineering CollegeSchool of Applied and Life Sciences, Uttaranchal UniversityDivision of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher EducationDepartment of Biotechnology, Graphic Era (Deemed to be University, Clement Town DehradunDepartment of Community Medicine and Health Care for Pilgrims, Faculty of Medicine, Umm Al-Qura UniversityInfection prevention and control centre of Excellence, Prince Sultan Medical Military CityDepartment of Pediatrics, College of Medicine, Taibah UniversityDepartment of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman UniversityCollege of Medicine and Health Science, Khalifa UniversityDepartment of Microbiology, National Reference laboratory, Cleveland clinic Abu DhabiDepartment of Pathology and Laboratory Medicine, Security Forces Hospital ProgramDepartment of Pathology and Laboratory Medicine, Security Forces Hospital ProgramSR Sanjeevani HospitalSchool of Pharmaceutical Sciences, Lovely Professional UniversityCenter for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Saveetha UniversityCenter for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Saveetha UniversityNoida Institute of Engineering and Technology (Pharmacy Institute)Centre of Research Impact and Outcome, Chitkara UniversityChitkara Centre for Research and Development, Chitkara UniversityClinical Microbiology, RDC, Manav Rachna International Institute of Research and StudiesResearch and Enterprise, University of CyberjayaIES Institute of Pharmacy, IES UniversityNew Delhi Institute of ManagementAbstract Background The COVID-19 pandemic has significantly impacted public health, with emerging evidence suggesting substantial effects on maternal and neonatal health. This systematic review and meta-analysis aimed to quantify the prevalence and risk of respiratory distress syndrome (RDS) in newborns born to mothers infected with SARS-CoV-2, the virus responsible for COVID-19. Methods We conducted a literature search in Embase, PubMed, and Web of Science up to April 20, without language or date restrictions. Observational studies reporting on the prevalence or risk of RDS among newborns from mothers with confirmed SARS-CoV-2 infection were included. Quality assessment was performed using the JBI tool. Statistical analysis was performed by using R software version 4.3. Results Twenty-two studies met the inclusion criteria. The pooled prevalence of RDS among newborns born to COVID-19-infected mothers was 11.5% (95% CI: 7.4–17.3%), with significant heterogeneity (I² = 93%). Newborns from infected mothers had a significantly higher risk of developing RDS, with a pooled risk ratio (RR) of 2.69 (95% CI: 1.77 to 4.17). Conclusion Newborns born to mothers with COVID-19 have a substantially increased risk of developing RDS. These findings emphasize the need for vigilant monitoring and appropriate management of pregnant women with COVID-19 to mitigate adverse neonatal outcomes.https://doi.org/10.1186/s12879-024-10161-1COVID-19Respiratory distress syndromeMeta-analysisGood health and well-being |
| spellingShingle | Muhammed Shabil Shilpa Gaidhane Suhas Ballal Sanjay Kumar Mahakshit Bhat Shilpa Sharma M Ravi Kumar Sarvesh Rustagi Mahalaqua Nazli Khatib Nishant Rai Mohammed Garout Nabiha A. Bouafia Amer Alshengeti Hayam A Alrasheed Nawal A. Al Kaabi Mubarak Alfaresi Ali Hazazi Ali A. Rabaan Sanjit Sah Sorabh Lakhanpal Ganesh Bushi Laksmi Thangavelu Nagavalli Chilakam Sakshi Pandey Manvinder Brar Rachana Mehta Ashok Kumar Balaraman Rukshar Syed Gajendra Sharma Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis BMC Infectious Diseases COVID-19 Respiratory distress syndrome Meta-analysis Good health and well-being |
| title | Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis |
| title_full | Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis |
| title_fullStr | Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis |
| title_full_unstemmed | Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis |
| title_short | Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis |
| title_sort | maternal covid 19 infection and risk of respiratory distress syndrome among newborns a systematic review and meta analysis |
| topic | COVID-19 Respiratory distress syndrome Meta-analysis Good health and well-being |
| url | https://doi.org/10.1186/s12879-024-10161-1 |
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