Evaluation of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA Associated Rheumatic Diseases
Aim: In this study we aimed to find the frequency of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA associated rheumatic diseases (AARDs).Methods: In this study, 337 subjects who were evaluated in a rheumatology clinic with prediagnosis of rheumatic diseases with positive...
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Alanya Alaaddin Keykubat University
2021-12-01
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| Series: | Acta Medica Alanya |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/1825698 |
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| author | Sevcan Uğur Tuğba Kula Atik |
| author_facet | Sevcan Uğur Tuğba Kula Atik |
| author_sort | Sevcan Uğur |
| collection | DOAJ |
| description | Aim: In this study we aimed to find the frequency of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA associated rheumatic diseases (AARDs).Methods: In this study, 337 subjects who were evaluated in a rheumatology clinic with prediagnosis of rheumatic diseases with positive ANA test and had concurrent anti-extractable nuclear antigen (anti-ENA) antibodies results were retrospectively analyzed. Clinical diagnosis of patients and demographic characteristics were obtained from the patients' medical records.Results: A total of 337 subjects (305 women, 32 men) were included in this study. The mean age was 49.8 ± 14.2 years. Of the 337 participants, 111 (32.9%) had an IIF-DFS pattern and 226 (67.1%) had a non-DFS pattern. Anti-DFS70 antibodies were positive in 20.1% of individuals. Sixty eight individuals had AARDs. An IIF-DFS pattern was observed in 22.1% and a non-DFS pattern was observed in 77.9% of individuals with AARDs (p <0.05). Anti-DFS70 antibodies were positive in 13.2% of patients with AARDs. The frequency of AARDs was significantly lower in individuals with anti-DFS70 antibodies compared to individuals with other anti-ENAs antibodies (p <0.05).Conclusion: Anti-DFS70 antibodies may be present in patients with AARDs but AARDs are less prevalent in patients who had anti-DFS70 antibodies, compared with patients who had other anti-ENAs. |
| format | Article |
| id | doaj-art-262ea46db9404f81ab669f0b1d5837b1 |
| institution | Kabale University |
| issn | 2587-0319 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Alanya Alaaddin Keykubat University |
| record_format | Article |
| series | Acta Medica Alanya |
| spelling | doaj-art-262ea46db9404f81ab669f0b1d5837b12025-08-20T03:53:22ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192021-12-015323423810.30565/medalanya.952813727Evaluation of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA Associated Rheumatic DiseasesSevcan Uğur0https://orcid.org/0000-0001-5617-629XTuğba Kula Atik1https://orcid.org/0000-0002-2433-1977Alaettin Keykubat Üniversitesi Tıp Fakültesi Romatoloji Bilim Dalı SBalıkesir Üniversitesi Tıp Fakültesi Mikrobiyoloji anabilim DalıAim: In this study we aimed to find the frequency of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA associated rheumatic diseases (AARDs).Methods: In this study, 337 subjects who were evaluated in a rheumatology clinic with prediagnosis of rheumatic diseases with positive ANA test and had concurrent anti-extractable nuclear antigen (anti-ENA) antibodies results were retrospectively analyzed. Clinical diagnosis of patients and demographic characteristics were obtained from the patients' medical records.Results: A total of 337 subjects (305 women, 32 men) were included in this study. The mean age was 49.8 ± 14.2 years. Of the 337 participants, 111 (32.9%) had an IIF-DFS pattern and 226 (67.1%) had a non-DFS pattern. Anti-DFS70 antibodies were positive in 20.1% of individuals. Sixty eight individuals had AARDs. An IIF-DFS pattern was observed in 22.1% and a non-DFS pattern was observed in 77.9% of individuals with AARDs (p <0.05). Anti-DFS70 antibodies were positive in 13.2% of patients with AARDs. The frequency of AARDs was significantly lower in individuals with anti-DFS70 antibodies compared to individuals with other anti-ENAs antibodies (p <0.05).Conclusion: Anti-DFS70 antibodies may be present in patients with AARDs but AARDs are less prevalent in patients who had anti-DFS70 antibodies, compared with patients who had other anti-ENAs.https://dergipark.org.tr/tr/download/article-file/1825698antinuclear antibodies (anaanti-dfs70 antibodydfs patternanti nükleer antikor (ana)anti dfs70 antikordfs patern |
| spellingShingle | Sevcan Uğur Tuğba Kula Atik Evaluation of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA Associated Rheumatic Diseases Acta Medica Alanya antinuclear antibodies (ana anti-dfs70 antibody dfs pattern anti nükleer antikor (ana) anti dfs70 antikor dfs patern |
| title | Evaluation of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA Associated Rheumatic Diseases |
| title_full | Evaluation of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA Associated Rheumatic Diseases |
| title_fullStr | Evaluation of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA Associated Rheumatic Diseases |
| title_full_unstemmed | Evaluation of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA Associated Rheumatic Diseases |
| title_short | Evaluation of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA Associated Rheumatic Diseases |
| title_sort | evaluation of anti dfs70 antibodies and dfs pattern in ana positive individuals and ana associated rheumatic diseases |
| topic | antinuclear antibodies (ana anti-dfs70 antibody dfs pattern anti nükleer antikor (ana) anti dfs70 antikor dfs patern |
| url | https://dergipark.org.tr/tr/download/article-file/1825698 |
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