Pathogenesis, diagnosis and treatment of immune checkpoint inhibitor related bullous pemphigoid
As a new type of anti-tumor therapy, immune checkpoint inhibitor (ICI) can effectively improve the survival rate of tumor patients, but also bring a series of adverse reactions. Among these, immune-related cutaneous adverse events are prevalent. There is a relatively low incidence of bullous pemphig...
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| Format: | Article |
| Language: | English |
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Shanghai Chinese Clinical Medicine Press Co., Ltd.
2025-04-01
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| Series: | Zhongguo Linchuang Yixue |
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| Online Access: | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241038 |
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| _version_ | 1849310715692711936 |
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| author | Yi SUN Ji YANG |
| author_facet | Yi SUN Ji YANG |
| author_sort | Yi SUN |
| collection | DOAJ |
| description | As a new type of anti-tumor therapy, immune checkpoint inhibitor (ICI) can effectively improve the survival rate of tumor patients, but also bring a series of adverse reactions. Among these, immune-related cutaneous adverse events are prevalent. There is a relatively low incidence of bullous pemphigoid (BP) induced by ICI. However, this adverse event may not only negatively impact patient quality of life of patient, but also lead to treatment interruptions or discontinuations. This paper reviews the pathogenesis, prevalence, clinical manifestations, management methods of BP induced by ICI and its effect on tumor immunotherapy. |
| format | Article |
| id | doaj-art-262c361997b34d97bd512d3fcf935b50 |
| institution | Kabale University |
| issn | 1008-6358 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Shanghai Chinese Clinical Medicine Press Co., Ltd. |
| record_format | Article |
| series | Zhongguo Linchuang Yixue |
| spelling | doaj-art-262c361997b34d97bd512d3fcf935b502025-08-20T03:53:39ZengShanghai Chinese Clinical Medicine Press Co., Ltd.Zhongguo Linchuang Yixue1008-63582025-04-0132229529910.12025/j.issn.1008-6358.2025.2024103820241038Pathogenesis, diagnosis and treatment of immune checkpoint inhibitor related bullous pemphigoidYi SUN0Ji YANG1Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Dermatology, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaAs a new type of anti-tumor therapy, immune checkpoint inhibitor (ICI) can effectively improve the survival rate of tumor patients, but also bring a series of adverse reactions. Among these, immune-related cutaneous adverse events are prevalent. There is a relatively low incidence of bullous pemphigoid (BP) induced by ICI. However, this adverse event may not only negatively impact patient quality of life of patient, but also lead to treatment interruptions or discontinuations. This paper reviews the pathogenesis, prevalence, clinical manifestations, management methods of BP induced by ICI and its effect on tumor immunotherapy.https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241038bullous pemphigoidimmune checkpoint inhibitortumor immunotherapycutaneous adverse reaction |
| spellingShingle | Yi SUN Ji YANG Pathogenesis, diagnosis and treatment of immune checkpoint inhibitor related bullous pemphigoid Zhongguo Linchuang Yixue bullous pemphigoid immune checkpoint inhibitor tumor immunotherapy cutaneous adverse reaction |
| title | Pathogenesis, diagnosis and treatment of immune checkpoint inhibitor related bullous pemphigoid |
| title_full | Pathogenesis, diagnosis and treatment of immune checkpoint inhibitor related bullous pemphigoid |
| title_fullStr | Pathogenesis, diagnosis and treatment of immune checkpoint inhibitor related bullous pemphigoid |
| title_full_unstemmed | Pathogenesis, diagnosis and treatment of immune checkpoint inhibitor related bullous pemphigoid |
| title_short | Pathogenesis, diagnosis and treatment of immune checkpoint inhibitor related bullous pemphigoid |
| title_sort | pathogenesis diagnosis and treatment of immune checkpoint inhibitor related bullous pemphigoid |
| topic | bullous pemphigoid immune checkpoint inhibitor tumor immunotherapy cutaneous adverse reaction |
| url | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241038 |
| work_keys_str_mv | AT yisun pathogenesisdiagnosisandtreatmentofimmunecheckpointinhibitorrelatedbullouspemphigoid AT jiyang pathogenesisdiagnosisandtreatmentofimmunecheckpointinhibitorrelatedbullouspemphigoid |