COVID-19 vaccine acceptance and hesitancy in Cameroon: a systematic review and meta-analysis
Abstract Background The development of effective vaccines was a promising tool for ending the pandemic. However, the success of a vaccination programme hinges on achieving substantial community acceptance. In Cameroon, numerous studies have investigated the level of acceptance, hesitancy, and percep...
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BMC
2025-03-01
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| Online Access: | https://doi.org/10.1186/s12889-025-22195-4 |
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| author | Fabrice Zobel Lekeumo Cheuyem Adidja Amani Iyawa Clarisse Alma Nkodo Lionel Bethold Keubou Boukeng Michel Franck Edzamba Ariane Nouko Edwige Omona Guissana Christelle Sandrine Ngos Chabeja Achangwa Christian Mouangue |
| author_facet | Fabrice Zobel Lekeumo Cheuyem Adidja Amani Iyawa Clarisse Alma Nkodo Lionel Bethold Keubou Boukeng Michel Franck Edzamba Ariane Nouko Edwige Omona Guissana Christelle Sandrine Ngos Chabeja Achangwa Christian Mouangue |
| author_sort | Fabrice Zobel Lekeumo Cheuyem |
| collection | DOAJ |
| description | Abstract Background The development of effective vaccines was a promising tool for ending the pandemic. However, the success of a vaccination programme hinges on achieving substantial community acceptance. In Cameroon, numerous studies have investigated the level of acceptance, hesitancy, and perception of COVID-19 vaccines, with mixed results. To provide a comprehensive understanding of these parameters, this meta-analysis aimed to estimate the pooled proportion of COVID-19 vaccine acceptance, hesitancy and perception in Cameroon. Methods A systematic search of online databases, including PubMed, Google Scholar, and ScienceDirect, was conducted to identify relevant research articles. This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The extracted data were compiled in a Microsoft Excel spreadsheet and analyzed using R statistical software (version 4.3.3). The pooled proportion of COVID-19 vaccine acceptance, hesitancy, and perception was calculated using a random-effects meta-analysis. Funnel plots, Egger’s, and Begg’s tests were used to assess publication bias. Results Of the 1,346 records identified through the database search, 20 research articles were included in the systematic review and meta-analysis. The random-effects model showed that approximately 31.21% (95% CI: 23.49–38.94) of the participants was willing to accept the COVID-19 vaccine. More than two-thirds of the population (68.49%; 95% CI: 60.65–76.34) were vaccine hesitant. Half of the participants (51.81%; 95% CI: 42.70-60.93), had a negative perception of the COVID-19 vaccine. The acceptance rate progressed from the first semester of 2021 (27.21%; 95% CI: 10.38–44.05) to the first semester of 2022 (45.56%; 95% CI: 25.00-66.12). The pooled vaccine acceptance rate was 29.29% (95% CI: 19.86–38.72) for the general population and 39.24% (95% CI: 22.84–55.64) for healthcare workers. The pooled vaccine hesitancy rate was 70.39% (95% CI: 61.30–79.80) for the general population and 57.42% (95% CI: 4.05–71.80) for healthcare workers. Conclusion Although progress in vaccine acceptance, targeted interventions remain necessary to address vaccine hesitancy in the country. Strategies such as enhancing access to accurate information, fostering trust in institutions, and strengthening community engagement remain crucial for increasing COVID-19 vaccine uptake. |
| format | Article |
| id | doaj-art-262a939e839f4a94b3fbd1f3f8df146c |
| institution | DOAJ |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
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| spelling | doaj-art-262a939e839f4a94b3fbd1f3f8df146c2025-08-20T02:41:26ZengBMCBMC Public Health1471-24582025-03-0125111210.1186/s12889-025-22195-4COVID-19 vaccine acceptance and hesitancy in Cameroon: a systematic review and meta-analysisFabrice Zobel Lekeumo Cheuyem0Adidja Amani1Iyawa Clarisse Alma Nkodo2Lionel Bethold Keubou Boukeng3Michel Franck Edzamba4Ariane Nouko5Edwige Omona Guissana6Christelle Sandrine Ngos7Chabeja Achangwa8Christian Mouangue9Department of Public Health, Faculty of Medicine and Biomedical Sciences, The University of Yaounde IDepartment of Public Health, Faculty of Medicine and Biomedical Sciences, The University of Yaounde IMinistry of Public HealthDepartment of Public Health and Social Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of EbolowaDepartment of Public Health, Faculty of Medicine and Biomedical Sciences, The University of Yaounde IDepartment of Public Health, Faculty of Medicine and Biomedical Sciences, The University of Yaounde IMinistry of Public HealthDepartment of Public Health, Faculty of Medicine and Biomedical Sciences, The University of Yaounde IQueens Elisabeth Commonwealth Scholar (QECS Scholar), University of the West IndiesMinistry of Public HealthAbstract Background The development of effective vaccines was a promising tool for ending the pandemic. However, the success of a vaccination programme hinges on achieving substantial community acceptance. In Cameroon, numerous studies have investigated the level of acceptance, hesitancy, and perception of COVID-19 vaccines, with mixed results. To provide a comprehensive understanding of these parameters, this meta-analysis aimed to estimate the pooled proportion of COVID-19 vaccine acceptance, hesitancy and perception in Cameroon. Methods A systematic search of online databases, including PubMed, Google Scholar, and ScienceDirect, was conducted to identify relevant research articles. This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The extracted data were compiled in a Microsoft Excel spreadsheet and analyzed using R statistical software (version 4.3.3). The pooled proportion of COVID-19 vaccine acceptance, hesitancy, and perception was calculated using a random-effects meta-analysis. Funnel plots, Egger’s, and Begg’s tests were used to assess publication bias. Results Of the 1,346 records identified through the database search, 20 research articles were included in the systematic review and meta-analysis. The random-effects model showed that approximately 31.21% (95% CI: 23.49–38.94) of the participants was willing to accept the COVID-19 vaccine. More than two-thirds of the population (68.49%; 95% CI: 60.65–76.34) were vaccine hesitant. Half of the participants (51.81%; 95% CI: 42.70-60.93), had a negative perception of the COVID-19 vaccine. The acceptance rate progressed from the first semester of 2021 (27.21%; 95% CI: 10.38–44.05) to the first semester of 2022 (45.56%; 95% CI: 25.00-66.12). The pooled vaccine acceptance rate was 29.29% (95% CI: 19.86–38.72) for the general population and 39.24% (95% CI: 22.84–55.64) for healthcare workers. The pooled vaccine hesitancy rate was 70.39% (95% CI: 61.30–79.80) for the general population and 57.42% (95% CI: 4.05–71.80) for healthcare workers. Conclusion Although progress in vaccine acceptance, targeted interventions remain necessary to address vaccine hesitancy in the country. Strategies such as enhancing access to accurate information, fostering trust in institutions, and strengthening community engagement remain crucial for increasing COVID-19 vaccine uptake.https://doi.org/10.1186/s12889-025-22195-4COVID-19 vaccineAcceptanceHesitancyPerceptionCameroon |
| spellingShingle | Fabrice Zobel Lekeumo Cheuyem Adidja Amani Iyawa Clarisse Alma Nkodo Lionel Bethold Keubou Boukeng Michel Franck Edzamba Ariane Nouko Edwige Omona Guissana Christelle Sandrine Ngos Chabeja Achangwa Christian Mouangue COVID-19 vaccine acceptance and hesitancy in Cameroon: a systematic review and meta-analysis BMC Public Health COVID-19 vaccine Acceptance Hesitancy Perception Cameroon |
| title | COVID-19 vaccine acceptance and hesitancy in Cameroon: a systematic review and meta-analysis |
| title_full | COVID-19 vaccine acceptance and hesitancy in Cameroon: a systematic review and meta-analysis |
| title_fullStr | COVID-19 vaccine acceptance and hesitancy in Cameroon: a systematic review and meta-analysis |
| title_full_unstemmed | COVID-19 vaccine acceptance and hesitancy in Cameroon: a systematic review and meta-analysis |
| title_short | COVID-19 vaccine acceptance and hesitancy in Cameroon: a systematic review and meta-analysis |
| title_sort | covid 19 vaccine acceptance and hesitancy in cameroon a systematic review and meta analysis |
| topic | COVID-19 vaccine Acceptance Hesitancy Perception Cameroon |
| url | https://doi.org/10.1186/s12889-025-22195-4 |
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