Individualized transcranial temporal interference stimulation (tTIS) for cognitive impairments and negative symptoms in patients with schizophrenia: a study protocol for a randomized controlled trial

Individualized transcranial temporal interference stimulation (tTIS) for cognitive impairments and negative symptoms in patients with schizophrenia: a study protocol for a randomized controlled trial

Abstract Background Cognitive deficits and negative symptoms are core features of schizophrenia (SCZ) and remain major therapeutic challenges due to their limited responsiveness to antipsychotic medications. Transcranial temporal interference stimulation (tTIS) is a novel, non-invasive brain stimula...

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Bibliographic Details
Main Authors:	Shuzhe Wang, Junhao Chen, Linxuan Wang, Jingxuan Liu, Lijun Wang, Wenjie Sun, Shen Li, Jie Li
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	BMC Psychiatry
Subjects:	Schizophrenia Temporal interference stimulation Non-invasive brain stimulation Cognitive impairments Negative symptoms Nucleus accumbens
Online Access:	https://doi.org/10.1186/s12888-025-07158-8
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