Immunogenicity of dupilumab in adult and pediatric patients with atopic dermatitis

Immunogenicity of dupilumab in adult and pediatric patients with atopic dermatitis

BackgroundDevelopment of anti-drug antibodies (ADAs) and neutralizing antibodies (NAbs) to monoclonal antibodies may adversely impact pharmacokinetics, efficacy, and/or safety.ObjectiveTo describe incidence, titer, and persistence of dupilumab ADAs and NAbs, and their effects on pharmacokinetics, ef...

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Main Authors: Mohamed A. Kamal, Matthew P. Kosloski, Ching-Ha Lai, Michael A. Partridge, Manoj Rajadhyaksha, Vanaja Kanamaluru, Ashish Bansal, Arsalan Shabbir, Brad Shumel, Marius Ardeleanu, Susan M. Richards, Hong Yan, Christine R. Xu, Ainara Rodríguez-Marco, Jing Xiao, Faisal A. Khokhar, Guy Gherardi, Elisa Babilonia, Jennifer Maloney, Eric Mortensen, Bolanle Akinlade, Ned Braunstein, Neil Stahl, Albert Torri, John D. Davis, A. Thomas DiCioccio
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
anti-drug antibody
ADA
atopic dermatitis
dupilumab
immunogenicity
neutralizing antibody
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1466372/full
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