Periodontal Pathogens Correlate with Rheumatoid Arthritis Disease Parameters: A Systematic Review Based on Clinical Studies
<b>Background</b>: Numerous studies have found higher levels of autoantibodies including anti citrullinated protein antibodies (ACPAs), anti-cyclic citrullinated peptides (aCCP), or rheumatoid factor (RF) against periodontal microorganisms in rheumatoid arthritis (RA). Objective: To eval...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Dentistry Journal |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6767/13/5/214 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <b>Background</b>: Numerous studies have found higher levels of autoantibodies including anti citrullinated protein antibodies (ACPAs), anti-cyclic citrullinated peptides (aCCP), or rheumatoid factor (RF) against periodontal microorganisms in rheumatoid arthritis (RA). Objective: To evaluate the correlation between periodontal bacteria and RA disease parameters. <b>Methods</b>: We utilized PubMed, Scopus, ScienceDirect, and manual search databases up until March 2024 using PRISMA 2020 guidelines. The data were obtained from microbiological assays by RT-PCR/qPCR, sequencing, and serological testing of disease parameters (ACPA, aCCP, and RF) utilizing ELISA method. <b>Results</b>: A total of 1514 documents were discovered based on the inclusion criteria. <i>Porphyromonas gingivalis</i>, <i>Aggregatibacter actinomycetemcomitans</i>, and <i>Prevotella_9</i> were associated with elevated levels of ACPA/aCCP and RF in RA with periodontitis. A positive correlation was found between <i>Peptococcus simiae</i>, <i>Aminipila butyrica</i>, <i>Leptotrichia</i> spp., <i>Leptotrichia wadei</i>, and <i>Neisseria bacilliformis</i> with ACPA, and <i>Treponema</i> sp. canine oral taxon 087 with RF. <b>Conclusions</b>: This study found that several oral microorganisms correlate with elevated ACPA/aCCP and RF in RA with periodontitis. Future studies of the oral microbiome and the molecular mechanisms are anticipated to discover new therapies and diagnostic methods for periodontitis and RA. |
|---|---|
| ISSN: | 2304-6767 |