Inflammatory Profile of Awake Function-Controlled Craniotomy and Craniotomy under General Anesthesia
Background. Surgical stress triggers an inflammatory response and releases mediators into human plasma such as interleukins (ILs). Awake craniotomy and craniotomy performed under general anesthesia may be associated with different levels of stress. Our aim was to investigate whether those procedures...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/670480 |
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| author | Markus Klimek Jaap W. Hol Stephan Wens Claudia Heijmans-Antonissen Sjoerd Niehof Arnaud J. Vincent Jan Klein Freek J. Zijlstra |
| author_facet | Markus Klimek Jaap W. Hol Stephan Wens Claudia Heijmans-Antonissen Sjoerd Niehof Arnaud J. Vincent Jan Klein Freek J. Zijlstra |
| author_sort | Markus Klimek |
| collection | DOAJ |
| description | Background. Surgical stress triggers an inflammatory response and releases mediators into human plasma such as interleukins (ILs). Awake craniotomy and craniotomy performed under general anesthesia may be associated with different levels of stress. Our aim was to investigate whether those procedures cause different inflammatory responses.
Methods. Twenty patients undergoing craniotomy under general anesthesia and 20 patients undergoing awake function-controlled craniotomy were included in this prospective, observational, two-armed study. Circulating levels of IL-6, IL-8, and IL-10 were determined pre-, peri-, and postoperatively in both patient groups. VAS scores for pain, anxiety, and stress were taken at four moments pre- and postoperatively to evaluate physical pain and mental duress.
Results. Plasma IL-6 level significantly increased with time similarly in both groups. No significant plasma IL-8 and IL-10 change was observed in both experimental groups. The VAS pain score was significantly lower in the awake group compared to the anesthesia group at 12 hours postoperative. Postoperative anxiety and stress declined similarly in both groups.
Conclusion. This study suggests that awake function-controlled craniotomy does not cause a significantly different inflammatory response than craniotomy performed under general anesthesia. It is also likely that function-controlled craniotomy does not cause a greater emotional challenge than tumor resection under general anesthesia. |
| format | Article |
| id | doaj-art-26126aecbc3249598821e3cf31426cdc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-26126aecbc3249598821e3cf31426cdc2025-02-03T05:59:12ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/670480670480Inflammatory Profile of Awake Function-Controlled Craniotomy and Craniotomy under General AnesthesiaMarkus Klimek0Jaap W. Hol1Stephan Wens2Claudia Heijmans-Antonissen3Sjoerd Niehof4Arnaud J. Vincent5Jan Klein6Freek J. Zijlstra7Department of Anesthesiology, Erasmus MC, P. O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Anesthesiology, Erasmus MC, P. O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Anesthesiology, Erasmus MC, P. O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Anesthesiology, Erasmus MC, P. O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Anesthesiology, Erasmus MC, P. O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Neurosurgery, Erasmus MC, P. O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Anesthesiology, Erasmus MC, P. O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Anesthesiology, Erasmus MC, P. O. Box 2040, 3000 CA Rotterdam, The NetherlandsBackground. Surgical stress triggers an inflammatory response and releases mediators into human plasma such as interleukins (ILs). Awake craniotomy and craniotomy performed under general anesthesia may be associated with different levels of stress. Our aim was to investigate whether those procedures cause different inflammatory responses. Methods. Twenty patients undergoing craniotomy under general anesthesia and 20 patients undergoing awake function-controlled craniotomy were included in this prospective, observational, two-armed study. Circulating levels of IL-6, IL-8, and IL-10 were determined pre-, peri-, and postoperatively in both patient groups. VAS scores for pain, anxiety, and stress were taken at four moments pre- and postoperatively to evaluate physical pain and mental duress. Results. Plasma IL-6 level significantly increased with time similarly in both groups. No significant plasma IL-8 and IL-10 change was observed in both experimental groups. The VAS pain score was significantly lower in the awake group compared to the anesthesia group at 12 hours postoperative. Postoperative anxiety and stress declined similarly in both groups. Conclusion. This study suggests that awake function-controlled craniotomy does not cause a significantly different inflammatory response than craniotomy performed under general anesthesia. It is also likely that function-controlled craniotomy does not cause a greater emotional challenge than tumor resection under general anesthesia.http://dx.doi.org/10.1155/2009/670480 |
| spellingShingle | Markus Klimek Jaap W. Hol Stephan Wens Claudia Heijmans-Antonissen Sjoerd Niehof Arnaud J. Vincent Jan Klein Freek J. Zijlstra Inflammatory Profile of Awake Function-Controlled Craniotomy and Craniotomy under General Anesthesia Mediators of Inflammation |
| title | Inflammatory Profile of Awake Function-Controlled Craniotomy and Craniotomy under General Anesthesia |
| title_full | Inflammatory Profile of Awake Function-Controlled Craniotomy and Craniotomy under General Anesthesia |
| title_fullStr | Inflammatory Profile of Awake Function-Controlled Craniotomy and Craniotomy under General Anesthesia |
| title_full_unstemmed | Inflammatory Profile of Awake Function-Controlled Craniotomy and Craniotomy under General Anesthesia |
| title_short | Inflammatory Profile of Awake Function-Controlled Craniotomy and Craniotomy under General Anesthesia |
| title_sort | inflammatory profile of awake function controlled craniotomy and craniotomy under general anesthesia |
| url | http://dx.doi.org/10.1155/2009/670480 |
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