No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional study
BackgroundPrimary liver cancer (PLC) is one of the most common cancers worldwide. ABO blood groups and rhesus (Rh) factor are inherited characteristics. Their association with the presence of PLC remains unclear in cirrhotic patients. Hence, the purpose of this cross-sectional study was to evaluate...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1432137/full |
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| author | Liyan Dong Liyan Dong Yuhang Yin Yuhang Yin Huiyuan Lu Huiyuan Lu Di Sun Di Sun Dongyang Wang Deli Zou Xingshun Qi |
| author_facet | Liyan Dong Liyan Dong Yuhang Yin Yuhang Yin Huiyuan Lu Huiyuan Lu Di Sun Di Sun Dongyang Wang Deli Zou Xingshun Qi |
| author_sort | Liyan Dong |
| collection | DOAJ |
| description | BackgroundPrimary liver cancer (PLC) is one of the most common cancers worldwide. ABO blood groups and rhesus (Rh) factor are inherited characteristics. Their association with the presence of PLC remains unclear in cirrhotic patients. Hence, the purpose of this cross-sectional study was to evaluate whether blood groups were risk factors for the presence of PLC in cirrhosis.MethodsPatients with liver cirrhosis who were consecutively admitted to the Department of Gastroenterology of the General Hospital of Northern Theater Command from 1 January 2010 to 30 June 2014 were retrospectively screened. Logistic regression analyses were performed to explore the association of ABO blood groups and Rh factor with PLC in cirrhotic patients. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were calculated after adjusting for gender, age, family history of liver cirrhosis, HBV-DNA positivity, and etiology of cirrhosis. Subgroup analyses were performed according to the etiology of liver cirrhosis.ResultsOverall, 1,158 cirrhotic patients without PLC and 240 cirrhotic patients with PLC were included in the study. After adjusting for confounding factors, non-O (aOR = 0.763; 95%CI = 0.449–1.298, p = 0.319), A (aOR = 0.643; 95%CI = 0.332–1.246, p = 0.191), B (aOR = 0.835; 95%CI = 0.453–1.540, p = 0.564), AB (aOR = 0.888; 95%CI = 0.363–2.170, p = 0.795), and Rh (+) (aOR = 0.239; 95%CI = 0.036–1.571, p = 0.136) blood groups were not independently associated with PLC in cirrhotic patients. In the subgroup analysis of HBV-related cirrhotic patients, the proportion of A blood group was significantly lower in cirrhotic patients with PLC than in those without PLC (24.17% vs. 33.99%, p < 0.001); however, in HCV- and alcohol-related cirrhotic patients, the proportions of ABO blood groups and Rh factor were not significantly different between the two groups.ConclusionABO blood groups and Rh factor may not be associated with the presence of PLC in cirrhotic patients. |
| format | Article |
| id | doaj-art-26119dee85f943698706b74be8476a6f |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-26119dee85f943698706b74be8476a6f2025-01-22T04:11:12ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14321371432137No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional studyLiyan Dong0Liyan Dong1Yuhang Yin2Yuhang Yin3Huiyuan Lu4Huiyuan Lu5Di Sun6Di Sun7Dongyang Wang8Deli Zou9Xingshun Qi10Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, ChinaPostgraduate College, China Medical University, Shenyang, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, ChinaPostgraduate College, China Medical University, Shenyang, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, ChinaPostgraduate College, Shenyang Pharmaceutical University, Shenyang, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, ChinaPostgraduate College, Dalian Medical University, Dalian, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, ChinaBackgroundPrimary liver cancer (PLC) is one of the most common cancers worldwide. ABO blood groups and rhesus (Rh) factor are inherited characteristics. Their association with the presence of PLC remains unclear in cirrhotic patients. Hence, the purpose of this cross-sectional study was to evaluate whether blood groups were risk factors for the presence of PLC in cirrhosis.MethodsPatients with liver cirrhosis who were consecutively admitted to the Department of Gastroenterology of the General Hospital of Northern Theater Command from 1 January 2010 to 30 June 2014 were retrospectively screened. Logistic regression analyses were performed to explore the association of ABO blood groups and Rh factor with PLC in cirrhotic patients. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were calculated after adjusting for gender, age, family history of liver cirrhosis, HBV-DNA positivity, and etiology of cirrhosis. Subgroup analyses were performed according to the etiology of liver cirrhosis.ResultsOverall, 1,158 cirrhotic patients without PLC and 240 cirrhotic patients with PLC were included in the study. After adjusting for confounding factors, non-O (aOR = 0.763; 95%CI = 0.449–1.298, p = 0.319), A (aOR = 0.643; 95%CI = 0.332–1.246, p = 0.191), B (aOR = 0.835; 95%CI = 0.453–1.540, p = 0.564), AB (aOR = 0.888; 95%CI = 0.363–2.170, p = 0.795), and Rh (+) (aOR = 0.239; 95%CI = 0.036–1.571, p = 0.136) blood groups were not independently associated with PLC in cirrhotic patients. In the subgroup analysis of HBV-related cirrhotic patients, the proportion of A blood group was significantly lower in cirrhotic patients with PLC than in those without PLC (24.17% vs. 33.99%, p < 0.001); however, in HCV- and alcohol-related cirrhotic patients, the proportions of ABO blood groups and Rh factor were not significantly different between the two groups.ConclusionABO blood groups and Rh factor may not be associated with the presence of PLC in cirrhotic patients.https://www.frontiersin.org/articles/10.3389/fmed.2024.1432137/fullABO blood groupsrhesus factorprimary liver cancerliver cirrhosisrisk factor |
| spellingShingle | Liyan Dong Liyan Dong Yuhang Yin Yuhang Yin Huiyuan Lu Huiyuan Lu Di Sun Di Sun Dongyang Wang Deli Zou Xingshun Qi No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional study Frontiers in Medicine ABO blood groups rhesus factor primary liver cancer liver cirrhosis risk factor |
| title | No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional study |
| title_full | No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional study |
| title_fullStr | No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional study |
| title_full_unstemmed | No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional study |
| title_short | No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional study |
| title_sort | no association of abo blood groups and rh factor with primary liver cancer in cirrhotic patients a single center cross sectional study |
| topic | ABO blood groups rhesus factor primary liver cancer liver cirrhosis risk factor |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1432137/full |
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