Gastrointestinal Stromal Tumor Induced Hypercalcemia
Hypercalcemia in patients with cancer is a common laboratory finding affecting up to 44% of that patient population. 1,25-Dihydroxyvitamin D3 mediated hypercalcemia is one of the rare mechanisms of this endocrine emergency in cancer patients. It is even rarer for solid organ neoplasms to present wit...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/4972017 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850229003679432704 |
|---|---|
| author | Aram Barbaryan Stefania Bailuc Padma Poddutoori Aida Richardson Aibek E. Mirrakhimov |
| author_facet | Aram Barbaryan Stefania Bailuc Padma Poddutoori Aida Richardson Aibek E. Mirrakhimov |
| author_sort | Aram Barbaryan |
| collection | DOAJ |
| description | Hypercalcemia in patients with cancer is a common laboratory finding affecting up to 44% of that patient population. 1,25-Dihydroxyvitamin D3 mediated hypercalcemia is one of the rare mechanisms of this endocrine emergency in cancer patients. It is even rarer for solid organ neoplasms to present with hypercalcemia mediated through the production of 1,25-dihydroxyvitamin D3. We report a case of a 77-year-old female who presented to the hospital with hypercalcemia and later was found to have metastatic gastrointestinal stromal tumor. There have been only 5 cases of gastrointestinal stromal tumor described in literature resulting in hypercalcemia. In our case, the mechanism of hypercalcemia was thought to be related to overproduction of 1,25-dihydroxyvitamin by tumor cells. The patient had a favorable response to imatinib with normalization of serum calcium level. Unfortunately, she developed fluid retention due to imatinib which was discontinued resulting in relapse of hypercalcemia that was resistant to all other treatment options. |
| format | Article |
| id | doaj-art-260fe38d59bd4edc8eae960063bb4b6c |
| institution | OA Journals |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-260fe38d59bd4edc8eae960063bb4b6c2025-08-20T02:04:21ZengWileyCase Reports in Oncological Medicine2090-67062090-67142017-01-01201710.1155/2017/49720174972017Gastrointestinal Stromal Tumor Induced HypercalcemiaAram Barbaryan0Stefania Bailuc1Padma Poddutoori2Aida Richardson3Aibek E. Mirrakhimov4Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USADepartment of Medicine, HSHS Saint Mary’s Hospital, Decatur, IL, USADepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USADepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USADepartment of Medicine, University of Kentucky, Lexington, KY, USAHypercalcemia in patients with cancer is a common laboratory finding affecting up to 44% of that patient population. 1,25-Dihydroxyvitamin D3 mediated hypercalcemia is one of the rare mechanisms of this endocrine emergency in cancer patients. It is even rarer for solid organ neoplasms to present with hypercalcemia mediated through the production of 1,25-dihydroxyvitamin D3. We report a case of a 77-year-old female who presented to the hospital with hypercalcemia and later was found to have metastatic gastrointestinal stromal tumor. There have been only 5 cases of gastrointestinal stromal tumor described in literature resulting in hypercalcemia. In our case, the mechanism of hypercalcemia was thought to be related to overproduction of 1,25-dihydroxyvitamin by tumor cells. The patient had a favorable response to imatinib with normalization of serum calcium level. Unfortunately, she developed fluid retention due to imatinib which was discontinued resulting in relapse of hypercalcemia that was resistant to all other treatment options.http://dx.doi.org/10.1155/2017/4972017 |
| spellingShingle | Aram Barbaryan Stefania Bailuc Padma Poddutoori Aida Richardson Aibek E. Mirrakhimov Gastrointestinal Stromal Tumor Induced Hypercalcemia Case Reports in Oncological Medicine |
| title | Gastrointestinal Stromal Tumor Induced Hypercalcemia |
| title_full | Gastrointestinal Stromal Tumor Induced Hypercalcemia |
| title_fullStr | Gastrointestinal Stromal Tumor Induced Hypercalcemia |
| title_full_unstemmed | Gastrointestinal Stromal Tumor Induced Hypercalcemia |
| title_short | Gastrointestinal Stromal Tumor Induced Hypercalcemia |
| title_sort | gastrointestinal stromal tumor induced hypercalcemia |
| url | http://dx.doi.org/10.1155/2017/4972017 |
| work_keys_str_mv | AT arambarbaryan gastrointestinalstromaltumorinducedhypercalcemia AT stefaniabailuc gastrointestinalstromaltumorinducedhypercalcemia AT padmapoddutoori gastrointestinalstromaltumorinducedhypercalcemia AT aidarichardson gastrointestinalstromaltumorinducedhypercalcemia AT aibekemirrakhimov gastrointestinalstromaltumorinducedhypercalcemia |