The immune response to Francisella tularensis
Francisella tularensis (Ft) is a Gram negative intracellular bacterial pathogen, commonly transmitted via arthropod bites, but is most lethal when contracted via inhalation. The nature of a Gram-negative intracellular pathogen presents unique challenges to the mammalian immune response, unlike more...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1549343/full |
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| author | Derek A. Barthels Derek A. Barthels Robert V. House Robert V. House H. Carl Gelhaus |
| author_facet | Derek A. Barthels Derek A. Barthels Robert V. House Robert V. House H. Carl Gelhaus |
| author_sort | Derek A. Barthels |
| collection | DOAJ |
| description | Francisella tularensis (Ft) is a Gram negative intracellular bacterial pathogen, commonly transmitted via arthropod bites, but is most lethal when contracted via inhalation. The nature of a Gram-negative intracellular pathogen presents unique challenges to the mammalian immune response, unlike more common viral pathogens and extracellular bacterial pathogens. The current literature on Ft involves numerous variables, including the use of differing research strains and variation in animal models. This review aims to consolidate much of the recent literature on Ft to suggest promising research to better understand the complex immune response to this bacterium. |
| format | Article |
| id | doaj-art-260ba98acc8d462dbb087e4fcc68fc46 |
| institution | DOAJ |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-260ba98acc8d462dbb087e4fcc68fc462025-08-20T03:14:13ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-04-011610.3389/fmicb.2025.15493431549343The immune response to Francisella tularensisDerek A. Barthels0Derek A. Barthels1Robert V. House2Robert V. House3H. Carl Gelhaus4Department of Biology, Life Sciences Research Center, United States Air Force Academy, Colorado Springs, CO, United StatesNational Research Council Research Associateships Program, Washington, DC, United StatesDr. RV House LLC, Harpers Ferry, WV, United StatesAppili Therapeutics, Halifax, NS, CanadaAppili Therapeutics, Halifax, NS, CanadaFrancisella tularensis (Ft) is a Gram negative intracellular bacterial pathogen, commonly transmitted via arthropod bites, but is most lethal when contracted via inhalation. The nature of a Gram-negative intracellular pathogen presents unique challenges to the mammalian immune response, unlike more common viral pathogens and extracellular bacterial pathogens. The current literature on Ft involves numerous variables, including the use of differing research strains and variation in animal models. This review aims to consolidate much of the recent literature on Ft to suggest promising research to better understand the complex immune response to this bacterium.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1549343/fullFrancisella tularensistularemiaadaptive immunityinnate immunitycorrelates of protectionvaccine |
| spellingShingle | Derek A. Barthels Derek A. Barthels Robert V. House Robert V. House H. Carl Gelhaus The immune response to Francisella tularensis Frontiers in Microbiology Francisella tularensis tularemia adaptive immunity innate immunity correlates of protection vaccine |
| title | The immune response to Francisella tularensis |
| title_full | The immune response to Francisella tularensis |
| title_fullStr | The immune response to Francisella tularensis |
| title_full_unstemmed | The immune response to Francisella tularensis |
| title_short | The immune response to Francisella tularensis |
| title_sort | immune response to francisella tularensis |
| topic | Francisella tularensis tularemia adaptive immunity innate immunity correlates of protection vaccine |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1549343/full |
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