Fistuloclysis Improves Liver Function and Nutritional Status in Patients with High-Output Upper Enteric Fistula
Background. We aimed to determine the efficacy of fistuloclysis in patients with high-output upper enteric fistula (EF). Methods. Patients were assigned into the fistuloclysis group (n=35, receiving fistuloclysis plus total enteral nutrition (TEN)) and the control group (n=60, receiving TEN). Labora...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/941514 |
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| author | Yin Wu Jianan Ren Gefei Wang Bo Zhou Chao Ding Guosheng Gu Jun Chen Song Liu Jieshou Li |
| author_facet | Yin Wu Jianan Ren Gefei Wang Bo Zhou Chao Ding Guosheng Gu Jun Chen Song Liu Jieshou Li |
| author_sort | Yin Wu |
| collection | DOAJ |
| description | Background. We aimed to determine the efficacy of fistuloclysis in patients with high-output upper enteric fistula (EF). Methods. Patients were assigned into the fistuloclysis group (n=35, receiving fistuloclysis plus total enteral nutrition (TEN)) and the control group (n=60, receiving TEN). Laboratory variables were measured during the four-week treatment. Results. At baseline, variables were similar between the two groups. Delta value was defined as the changes from baseline to day 28. Compared with the control group, the fistuloclysis group showed greater improvements in liver function (Delta total bilirubin (TB): 20.3±9.7 in the fistuloclysis group versus 15.6±6.3 in the control group, P=0.040; Delta direct bilirubin (DB): 12.5±3.4 versus 10.0±3.6, P=0.011; Delta alkaline phosphatase (ALP): 98.4±33.5 versus 57.6±20.9, P<0.001); nutritional status (Delta total protein: 21.8±8.7 versus 10.7±2.1, P<0.001; Delta albumin: 11.3±2.5 versus 4.2±1.3, P<0.001). In the fistuloclysis subgroups, biliary fistula patients had the maximum number of variables with the greatest improvements. Conclusions. Fistuloclysis improved hepatic and nutritional parameters in patients with high-output upper EF, particularly in biliary fistula patients. |
| format | Article |
| id | doaj-art-2608a5637eae4706a2c9b538b9bd92f7 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-2608a5637eae4706a2c9b538b9bd92f72025-08-20T03:55:00ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/941514941514Fistuloclysis Improves Liver Function and Nutritional Status in Patients with High-Output Upper Enteric FistulaYin Wu0Jianan Ren1Gefei Wang2Bo Zhou3Chao Ding4Guosheng Gu5Jun Chen6Song Liu7Jieshou Li8Department of Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, ChinaDepartment of Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, ChinaDepartment of Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, ChinaDepartment of Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, ChinaDepartment of Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, ChinaDepartment of Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, ChinaDepartment of Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, ChinaDepartment of Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, ChinaDepartment of Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, ChinaBackground. We aimed to determine the efficacy of fistuloclysis in patients with high-output upper enteric fistula (EF). Methods. Patients were assigned into the fistuloclysis group (n=35, receiving fistuloclysis plus total enteral nutrition (TEN)) and the control group (n=60, receiving TEN). Laboratory variables were measured during the four-week treatment. Results. At baseline, variables were similar between the two groups. Delta value was defined as the changes from baseline to day 28. Compared with the control group, the fistuloclysis group showed greater improvements in liver function (Delta total bilirubin (TB): 20.3±9.7 in the fistuloclysis group versus 15.6±6.3 in the control group, P=0.040; Delta direct bilirubin (DB): 12.5±3.4 versus 10.0±3.6, P=0.011; Delta alkaline phosphatase (ALP): 98.4±33.5 versus 57.6±20.9, P<0.001); nutritional status (Delta total protein: 21.8±8.7 versus 10.7±2.1, P<0.001; Delta albumin: 11.3±2.5 versus 4.2±1.3, P<0.001). In the fistuloclysis subgroups, biliary fistula patients had the maximum number of variables with the greatest improvements. Conclusions. Fistuloclysis improved hepatic and nutritional parameters in patients with high-output upper EF, particularly in biliary fistula patients.http://dx.doi.org/10.1155/2014/941514 |
| spellingShingle | Yin Wu Jianan Ren Gefei Wang Bo Zhou Chao Ding Guosheng Gu Jun Chen Song Liu Jieshou Li Fistuloclysis Improves Liver Function and Nutritional Status in Patients with High-Output Upper Enteric Fistula Gastroenterology Research and Practice |
| title | Fistuloclysis Improves Liver Function and Nutritional Status in Patients with High-Output Upper Enteric Fistula |
| title_full | Fistuloclysis Improves Liver Function and Nutritional Status in Patients with High-Output Upper Enteric Fistula |
| title_fullStr | Fistuloclysis Improves Liver Function and Nutritional Status in Patients with High-Output Upper Enteric Fistula |
| title_full_unstemmed | Fistuloclysis Improves Liver Function and Nutritional Status in Patients with High-Output Upper Enteric Fistula |
| title_short | Fistuloclysis Improves Liver Function and Nutritional Status in Patients with High-Output Upper Enteric Fistula |
| title_sort | fistuloclysis improves liver function and nutritional status in patients with high output upper enteric fistula |
| url | http://dx.doi.org/10.1155/2014/941514 |
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