Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward
Tumors accumulate metabolites that deactivate infiltrating immune cells and polarize them toward anti-inflammatory phenotypes. We provide a comprehensive review of the complex networks orchestrated by several of the most potent immunosuppressive metabolites, highlighting the impact of adenosine, kyn...
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Main Authors: | David Munn, Maria Rain Jennings, John Blazeck |
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Format: | Article |
Language: | English |
Published: |
BMJ Publishing Group
2021-10-01
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Series: | Journal for ImmunoTherapy of Cancer |
Online Access: | https://jitc.bmj.com/content/9/10/e003013.full |
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