Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation

Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation

Backgroud: The E3 ubiquitin ligase casitas B lymphoma-b (Cbl-b) is pivotal in modulating immune responses by attenuating T-cell activation and cytokine production. Inhibiting Cbl-b presents a potential therapeutic strategy in immuno-oncology by enhancing immune activity.Methods: A rapid Homogeneous...

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Main Authors: Ting Yu, Li Jia, Wenting Zhu, Shan Lu, Yongliang Zhang, Benjin Liu, Shanshan Song, Xubin Bao, Zehong Miao, Jinxue He
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/5/e011180.full
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