Bacterial Vaginosis Bacterial and Epithelial Cell Adhesion Molecules

Lactobacilli are member of normal vaginal flora. They maintain low pH of vaginal discharge by metabolising glycogen in vaginal epithelial cell and protects the vagina against the pathogenic microorganisms. However, the vaginal flora can be changed because of birth, taking antibiotics and contracept...

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Main Authors: Şayeste Demirezen, Aydan Mutlu, Sinan Beksaç
Format: Article
Language:English
Published: Medical Network 2013-04-01
Series:Gynecology Obstetrics & Reproductive Medicine
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Online Access:https://gorm.com.tr/index.php/GORM/article/view/187
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author Şayeste Demirezen
Aydan Mutlu
Sinan Beksaç
author_facet Şayeste Demirezen
Aydan Mutlu
Sinan Beksaç
author_sort Şayeste Demirezen
collection DOAJ
description Lactobacilli are member of normal vaginal flora. They maintain low pH of vaginal discharge by metabolising glycogen in vaginal epithelial cell and protects the vagina against the pathogenic microorganisms. However, the vaginal flora can be changed because of birth, taking antibiotics and contraceptive pills. Thus, whereas Lactobacilli population decreases, Gardnerella vaginalis and mixed anaerobic bacteria population increase and this situation causes an infection named Bacterial vaginosis. In this infection, the main diagnostic criteria are clue cells. The clue cell is a squamous epithelial cell which is covered by bacteria. First step of infection progress is adhesion of bacteria to epithelial cell through the adhesion molecules. The most important adhesion molecules of epithelium are cadherins, fibronectins, Toll like receptors and carbohydrates. In bacteria, pilis, lypopolysaccaharide and biofilm have primary importance. In this review, the adhesion molecules are discussed in detail and their roles in formation of clue cell are clarified.
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institution Kabale University
issn 1300-4751
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publishDate 2013-04-01
publisher Medical Network
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series Gynecology Obstetrics & Reproductive Medicine
spelling doaj-art-25fa22d36a124652b630a6afb44383aa2025-02-11T21:20:04ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182013-04-01191126Bacterial Vaginosis Bacterial and Epithelial Cell Adhesion MoleculesŞayeste Demirezen0Aydan Mutlu1Sinan Beksaç2Hacettepe University, Faculty of Natural & Applied Science Department of Biology, AnkaraHacettepe University, Faculty of Natural & Applied Science Department of Biology, AnkaraHacettepe University, Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara Lactobacilli are member of normal vaginal flora. They maintain low pH of vaginal discharge by metabolising glycogen in vaginal epithelial cell and protects the vagina against the pathogenic microorganisms. However, the vaginal flora can be changed because of birth, taking antibiotics and contraceptive pills. Thus, whereas Lactobacilli population decreases, Gardnerella vaginalis and mixed anaerobic bacteria population increase and this situation causes an infection named Bacterial vaginosis. In this infection, the main diagnostic criteria are clue cells. The clue cell is a squamous epithelial cell which is covered by bacteria. First step of infection progress is adhesion of bacteria to epithelial cell through the adhesion molecules. The most important adhesion molecules of epithelium are cadherins, fibronectins, Toll like receptors and carbohydrates. In bacteria, pilis, lypopolysaccaharide and biofilm have primary importance. In this review, the adhesion molecules are discussed in detail and their roles in formation of clue cell are clarified. https://gorm.com.tr/index.php/GORM/article/view/187Bacterial vaginosisClue cellCadherinPiliBiofilm
spellingShingle Şayeste Demirezen
Aydan Mutlu
Sinan Beksaç
Bacterial Vaginosis Bacterial and Epithelial Cell Adhesion Molecules
Gynecology Obstetrics & Reproductive Medicine
Bacterial vaginosis
Clue cell
Cadherin
Pili
Biofilm
title Bacterial Vaginosis Bacterial and Epithelial Cell Adhesion Molecules
title_full Bacterial Vaginosis Bacterial and Epithelial Cell Adhesion Molecules
title_fullStr Bacterial Vaginosis Bacterial and Epithelial Cell Adhesion Molecules
title_full_unstemmed Bacterial Vaginosis Bacterial and Epithelial Cell Adhesion Molecules
title_short Bacterial Vaginosis Bacterial and Epithelial Cell Adhesion Molecules
title_sort bacterial vaginosis bacterial and epithelial cell adhesion molecules
topic Bacterial vaginosis
Clue cell
Cadherin
Pili
Biofilm
url https://gorm.com.tr/index.php/GORM/article/view/187
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AT aydanmutlu bacterialvaginosisbacterialandepithelialcelladhesionmolecules
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