Exosomal SPRY4 from adipogenic BMSCs impairs angiogenesis via the PTPRB/TIE2/PI3K axis in Steroid-induced osteonecrosis of the femoral head

Exosomal SPRY4 from adipogenic BMSCs impairs angiogenesis via the PTPRB/TIE2/PI3K axis in Steroid-induced osteonecrosis of the femoral head

Abstract Background Steroid-induced osteonecrosis of the femoral head (SONFH) drives irreversible bone collapse, yet current therapies inadequately target the disrupted angiogenic-osteogenic coupling central to its pathogenesis. Although pathological adipocyte hyperplasia is a hallmark of SONFH, the...

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Main Authors: Dulei Xiang, Yuandong Zhou, Hongwei Wang, Yu chen, Haobo Bai, Zihan Wang, Siyu Tan, Dong Wu, Wenlong Yan, Xiao Huang, Tingmei Chen, Chengjie Lian, Jian Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Steroid-induced osteonecrosis of the femoral head
Exosomes
Adipogenesis
Angiogenesis
SPRY4
PTPRB
Online Access:https://doi.org/10.1186/s13287-025-04505-0
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https://doi.org/10.1186/s13287-025-04505-0

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