Association Between <i>IL-28B</i> (rs8099917) and <i>IL-28B</i> (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis
This research addresses <i>IL-28B</i> gene polymorphisms (rs12979860 and rs8099917) to determine their association with HTLV-1-related diseases; it aims to compare genotypic frequencies to identify predisposition or protection, considering population, disease, and controls. Given HTLV-1’...
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MDPI AG
2025-05-01
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| Online Access: | https://www.mdpi.com/2076-0817/14/5/470 |
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| author | Naomi Cuenca Damarys Cordero Brenda López-Ulloa |
| author_facet | Naomi Cuenca Damarys Cordero Brenda López-Ulloa |
| author_sort | Naomi Cuenca |
| collection | DOAJ |
| description | This research addresses <i>IL-28B</i> gene polymorphisms (rs12979860 and rs8099917) to determine their association with HTLV-1-related diseases; it aims to compare genotypic frequencies to identify predisposition or protection, considering population, disease, and controls. Given HTLV-1’s impact on immunity, this study seeks biomarkers for early diagnosis and intervention. A systematic search met inclusion criteria, such as open access bibliographic and experimental studies published in English between 2010 and 2024, and genetic factors linked to susceptibility to pathologies. Regarding exclusion criteria, bibliographic or experimental studies in organisms other than humans, unofficial sources, non-indexed journals, and scientific articles in languages other than English were ruled out. Statistical data analyses were assessed using meta-analysis, including forest plot and Q test of heterogeneity based on the I<sup>2</sup> statistics. The analyzed data indicate associations between genotypes, such as CT, GG, CC, and TT of the rs12979890 and rs8099917 polymorphisms and the predisposition to various diseases, such as HCV, arthropathy, HAM/TSP, cytomegalovirus and Crimean–Congo hemorrhagic fever associated with HTLV-1; however, the observed inconsistencies, such as high heterogeneity, and deficiency of related information limit the consolidation of the findings. Further research is needed to clarify IL-28B genotype interactions and disease susceptibility in HTLV-1 infections. |
| format | Article |
| id | doaj-art-25ef751d023f41bcaa3fb9589ab91d8a |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-25ef751d023f41bcaa3fb9589ab91d8a2025-08-20T03:47:54ZengMDPI AGPathogens2076-08172025-05-0114547010.3390/pathogens14050470Association Between <i>IL-28B</i> (rs8099917) and <i>IL-28B</i> (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-AnalysisNaomi Cuenca0Damarys Cordero1Brenda López-Ulloa2Grupo de Investigación en Aplicaciones Biotecnológicas (GIAB), Universidad Politécnica Salesiana (UPS), Carrera de Biotecnología, Campus María Auxiliadora, Kilómetro 19.5 Vía a La Costa, Guayaquil P.O. Box 09-01-2074, EcuadorGrupo de Investigación en Aplicaciones Biotecnológicas (GIAB), Universidad Politécnica Salesiana (UPS), Carrera de Biotecnología, Campus María Auxiliadora, Kilómetro 19.5 Vía a La Costa, Guayaquil P.O. Box 09-01-2074, EcuadorGrupo de Investigación en Aplicaciones Biotecnológicas (GIAB), Universidad Politécnica Salesiana (UPS), Carrera de Biotecnología, Campus María Auxiliadora, Kilómetro 19.5 Vía a La Costa, Guayaquil P.O. Box 09-01-2074, EcuadorThis research addresses <i>IL-28B</i> gene polymorphisms (rs12979860 and rs8099917) to determine their association with HTLV-1-related diseases; it aims to compare genotypic frequencies to identify predisposition or protection, considering population, disease, and controls. Given HTLV-1’s impact on immunity, this study seeks biomarkers for early diagnosis and intervention. A systematic search met inclusion criteria, such as open access bibliographic and experimental studies published in English between 2010 and 2024, and genetic factors linked to susceptibility to pathologies. Regarding exclusion criteria, bibliographic or experimental studies in organisms other than humans, unofficial sources, non-indexed journals, and scientific articles in languages other than English were ruled out. Statistical data analyses were assessed using meta-analysis, including forest plot and Q test of heterogeneity based on the I<sup>2</sup> statistics. The analyzed data indicate associations between genotypes, such as CT, GG, CC, and TT of the rs12979890 and rs8099917 polymorphisms and the predisposition to various diseases, such as HCV, arthropathy, HAM/TSP, cytomegalovirus and Crimean–Congo hemorrhagic fever associated with HTLV-1; however, the observed inconsistencies, such as high heterogeneity, and deficiency of related information limit the consolidation of the findings. Further research is needed to clarify IL-28B genotype interactions and disease susceptibility in HTLV-1 infections.https://www.mdpi.com/2076-0817/14/5/470IL-28BHTLV-1HAM/TSPHTLV-1 related diseases |
| spellingShingle | Naomi Cuenca Damarys Cordero Brenda López-Ulloa Association Between <i>IL-28B</i> (rs8099917) and <i>IL-28B</i> (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis Pathogens IL-28B HTLV-1 HAM/TSP HTLV-1 related diseases |
| title | Association Between <i>IL-28B</i> (rs8099917) and <i>IL-28B</i> (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis |
| title_full | Association Between <i>IL-28B</i> (rs8099917) and <i>IL-28B</i> (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis |
| title_fullStr | Association Between <i>IL-28B</i> (rs8099917) and <i>IL-28B</i> (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association Between <i>IL-28B</i> (rs8099917) and <i>IL-28B</i> (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis |
| title_short | Association Between <i>IL-28B</i> (rs8099917) and <i>IL-28B</i> (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis |
| title_sort | association between i il 28b i rs8099917 and i il 28b i rs12979860 with predisposition to diseases related to the htlv 1 systematic review and meta analysis |
| topic | IL-28B HTLV-1 HAM/TSP HTLV-1 related diseases |
| url | https://www.mdpi.com/2076-0817/14/5/470 |
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