Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro‐Angiogenic Macrophage Polarization via Activation of the PI3K‐Akt Signaling Pathway

Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro‐Angiogenic Macrophage Polarization via Activation of the PI3K‐Akt Signaling Pathway

Abstract Regulation of the immune response is key to promoting bone regeneration by electroactive biomaterials. However, how electrical signals at the micro‐ and nanoscale regulate the immune response and subsequent angiogenesis during bone regeneration remains to be elucidated. Here, the distinctly...

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Main Authors: Qun Cui, Xiaona Zheng, Yunyang Bai, Yaru Guo, Shuo Liu, Yanhui Lu, Lulu Liu, Jia Song, Yang Liu, Boon Chin Heng, Fuping You, Mingming Xu, Xuliang Deng, Xuehui Zhang
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
angiogenesis
bone regeneration
heterogeneous surface potential distribution
PI3K‐Akt signaling pathway
pro‐angiogenic macrophage polarization
Online Access:https://doi.org/10.1002/advs.202414278
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