Multi-organ pathology in a small porcine model of cytokine storm syndrome characteristics

Multi-organ pathology in a small porcine model of cytokine storm syndrome characteristics

IntroductionCytokine Storm Syndrome (CSS) is a severe immune dysregulation characterized by excessive cytokine release and multi-organ injury. Existing murine models inadequately replicate human CSS. This study aimed to establish a D-galactosamine (D-GalN)-induced miniature pig model to investigate...

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Bibliographic Details
Main Authors: Jiaqian Jin, Linxiao Fan, Richai Chen, Xuanhao Lin, Sainan Zhang, Mengfei Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
cytokine storm syndrome (CSS)
D-galactosamine (D-GalN)
liver failure
interleukin-6 (IL-6)
histopathology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618665/full
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