The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy
Few studies have correlated serum biomarkers with renal histology, the gold standard for renal activity, in lupus nephritis (LN). We tested a panel of autoantibodies and complement at the time of kidney biopsy and after treatment. Anti-dsDNA, anti-nucleosome, anti-ribosome P, and anti-C1q antibodies...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/106904 |
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| author | Gabriella Moroni Silvana Quaglini Antonella Radice Barbara Trezzi Francesca Raffiotta Piergiorgio Messa Renato Alberto Sinico |
| author_facet | Gabriella Moroni Silvana Quaglini Antonella Radice Barbara Trezzi Francesca Raffiotta Piergiorgio Messa Renato Alberto Sinico |
| author_sort | Gabriella Moroni |
| collection | DOAJ |
| description | Few studies have correlated serum biomarkers with renal histology, the gold standard for renal activity, in lupus nephritis (LN). We tested a panel of autoantibodies and complement at the time of kidney biopsy and after treatment. Anti-dsDNA, anti-nucleosome, anti-ribosome P, and anti-C1q antibodies and C3/C4 were measured in 107 patients with LN at the time of renal biopsy and after 6–12 months and were correlated with clinical/histological parameters. At multivariate analysis, high titers of anti-C1q antibodies or of anti-dsDNA antibodies (P=0.005, OR = 8.67, CI: 2.03–37.3) were the independent predictors that discriminate proliferative from nonproliferative LN. All the immunological parameters, except anti-ribosome, showed a significant correlation with activity index but not with chronicity index. Only anti-C1q showed a significant correlation with the amount of proteinuria (R=0.2, P=0.03). None of the immunological parameters were predictive of remission at 6 and 12 months. We found that anti-C1q alone or in combination with anti-dsDNA emerged as the most reliable test in differentiating proliferative and nonproliferative LN. Anti-C1q was the only test correlated with the clinical presentation of LN. After treatment, the titre of the autoantibodies was significantly reduced, but none was predictive of remission. |
| format | Article |
| id | doaj-art-25e97d8ecd234c54ac4ba9e2a7c957ad |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-25e97d8ecd234c54ac4ba9e2a7c957ad2025-02-03T05:53:48ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/106904106904The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal BiopsyGabriella Moroni0Silvana Quaglini1Antonella Radice2Barbara Trezzi3Francesca Raffiotta4Piergiorgio Messa5Renato Alberto Sinico6Division of Nephrology, Fondazione Ospedale Maggiore, Mangiagalli, Regina Elena, 20122 Milano, ItalyDepartment of Informatics, Università degli Studi di Pavia, 27100 Pavia, ItalyInstitute of Microbiology, Azienda Ospedaliera, Ospedale San Carlo Borromeo, 20153 Milano, ItalyRenal Unit and Clinical Immunology Unit, Azienda Ospedaliera, Ospedale San Carlo Borromeo, 20153 Milano, ItalyDivision of Nephrology, Fondazione Ospedale Maggiore, Mangiagalli, Regina Elena, 20122 Milano, ItalyDivision of Nephrology, Fondazione Ospedale Maggiore, Mangiagalli, Regina Elena, 20122 Milano, ItalyRenal Unit and Clinical Immunology Unit, Azienda Ospedaliera, Ospedale San Carlo Borromeo, 20153 Milano, ItalyFew studies have correlated serum biomarkers with renal histology, the gold standard for renal activity, in lupus nephritis (LN). We tested a panel of autoantibodies and complement at the time of kidney biopsy and after treatment. Anti-dsDNA, anti-nucleosome, anti-ribosome P, and anti-C1q antibodies and C3/C4 were measured in 107 patients with LN at the time of renal biopsy and after 6–12 months and were correlated with clinical/histological parameters. At multivariate analysis, high titers of anti-C1q antibodies or of anti-dsDNA antibodies (P=0.005, OR = 8.67, CI: 2.03–37.3) were the independent predictors that discriminate proliferative from nonproliferative LN. All the immunological parameters, except anti-ribosome, showed a significant correlation with activity index but not with chronicity index. Only anti-C1q showed a significant correlation with the amount of proteinuria (R=0.2, P=0.03). None of the immunological parameters were predictive of remission at 6 and 12 months. We found that anti-C1q alone or in combination with anti-dsDNA emerged as the most reliable test in differentiating proliferative and nonproliferative LN. Anti-C1q was the only test correlated with the clinical presentation of LN. After treatment, the titre of the autoantibodies was significantly reduced, but none was predictive of remission.http://dx.doi.org/10.1155/2015/106904 |
| spellingShingle | Gabriella Moroni Silvana Quaglini Antonella Radice Barbara Trezzi Francesca Raffiotta Piergiorgio Messa Renato Alberto Sinico The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy Journal of Immunology Research |
| title | The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy |
| title_full | The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy |
| title_fullStr | The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy |
| title_full_unstemmed | The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy |
| title_short | The Value of a Panel of Autoantibodies for Predicting the Activity of Lupus Nephritis at Time of Renal Biopsy |
| title_sort | value of a panel of autoantibodies for predicting the activity of lupus nephritis at time of renal biopsy |
| url | http://dx.doi.org/10.1155/2015/106904 |
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