Palpitations, Shortness of Breath, Weakness in Limbs, Edema, and Dyspnea: A Rare Inflammatory Myopathy with Positive Aniti-mitochondrial Antibodies and Cardiac Involvement
This article presents a case study of a patient who visited the Geriatric Department of Peking Union Medical College Hospital due to "palpitations, shortness of breath for more than 2 years, limb weakness for 6 months, edema, and nocturnal dyspnea for 2 months". The patient exhibited decre...
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2025-01-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0078 |
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| author | LIANG Chunsu ZHANG Xuchang ZHANG Ning KANG Lin LIU Xiaohong YU Jiaqi LIU Yingxian QIAO Lin YANG Yanli ZHAO Xiaoyi ZHAO Ruijie NIU Na YAN Xuelian |
| author_facet | LIANG Chunsu ZHANG Xuchang ZHANG Ning KANG Lin LIU Xiaohong YU Jiaqi LIU Yingxian QIAO Lin YANG Yanli ZHAO Xiaoyi ZHAO Ruijie NIU Na YAN Xuelian |
| author_sort | LIANG Chunsu |
| collection | DOAJ |
| description | This article presents a case study of a patient who visited the Geriatric Department of Peking Union Medical College Hospital due to "palpitations, shortness of breath for more than 2 years, limb weakness for 6 months, edema, and nocturnal dyspnea for 2 months". The patient exhibited decreased muscle strength in the limbs and involvement of swallowing and respiratory muscles, alongside complications of heart failure and various arrhythmias which were predominantly atrial. Laboratory tests revealed the presence of multiple autoantibodies and notably anti-mitochondrial antibodies. Following a comprehensive multidisciplinary evaluation, the patient was diagnosed with anti-mitochondrial antibody-associated inflammatory myopathy. Treatment involved a combination of glucocorticoids and immunosuppressants, along with resistance exercises for muscle strength and rehabilitation training for lung function, resulting in significant improvement of clinical symptoms. The case underscores the importance of collaborative multidisciplinary approaches in diagnosing and treating rare diseases in elderly patients, where careful consideration of clinical manifestations and subtle abnormal clinical data can lead to effective interventions. |
| format | Article |
| id | doaj-art-25e50a9326bb4abc9aeb36f943af8964 |
| institution | Kabale University |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-25e50a9326bb4abc9aeb36f943af89642025-02-08T07:47:34ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812025-01-0116124825510.12290/xhyxzz.2024-0078Palpitations, Shortness of Breath, Weakness in Limbs, Edema, and Dyspnea: A Rare Inflammatory Myopathy with Positive Aniti-mitochondrial Antibodies and Cardiac InvolvementLIANG ChunsuZHANG XuchangZHANG Ning0KANG Lin1LIU Xiaohong2YU Jiaqi3LIU Yingxian4QIAO Lin5YANG Yanli6ZHAO Xiaoyi7ZHAO Ruijie8NIU Na9YAN Xuelian10Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Rehabilitation Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaThis article presents a case study of a patient who visited the Geriatric Department of Peking Union Medical College Hospital due to "palpitations, shortness of breath for more than 2 years, limb weakness for 6 months, edema, and nocturnal dyspnea for 2 months". The patient exhibited decreased muscle strength in the limbs and involvement of swallowing and respiratory muscles, alongside complications of heart failure and various arrhythmias which were predominantly atrial. Laboratory tests revealed the presence of multiple autoantibodies and notably anti-mitochondrial antibodies. Following a comprehensive multidisciplinary evaluation, the patient was diagnosed with anti-mitochondrial antibody-associated inflammatory myopathy. Treatment involved a combination of glucocorticoids and immunosuppressants, along with resistance exercises for muscle strength and rehabilitation training for lung function, resulting in significant improvement of clinical symptoms. The case underscores the importance of collaborative multidisciplinary approaches in diagnosing and treating rare diseases in elderly patients, where careful consideration of clinical manifestations and subtle abnormal clinical data can lead to effective interventions.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0078idiopathic inflammatory myopathyinflammatory myopathy associated with anti-mitochondrial antibodiesheart failurecardiac arrhythmiaselderly patientsshared decision making |
| spellingShingle | LIANG Chunsu ZHANG Xuchang ZHANG Ning KANG Lin LIU Xiaohong YU Jiaqi LIU Yingxian QIAO Lin YANG Yanli ZHAO Xiaoyi ZHAO Ruijie NIU Na YAN Xuelian Palpitations, Shortness of Breath, Weakness in Limbs, Edema, and Dyspnea: A Rare Inflammatory Myopathy with Positive Aniti-mitochondrial Antibodies and Cardiac Involvement Xiehe Yixue Zazhi idiopathic inflammatory myopathy inflammatory myopathy associated with anti-mitochondrial antibodies heart failure cardiac arrhythmias elderly patients shared decision making |
| title | Palpitations, Shortness of Breath, Weakness in Limbs, Edema, and Dyspnea: A Rare Inflammatory Myopathy with Positive Aniti-mitochondrial Antibodies and Cardiac Involvement |
| title_full | Palpitations, Shortness of Breath, Weakness in Limbs, Edema, and Dyspnea: A Rare Inflammatory Myopathy with Positive Aniti-mitochondrial Antibodies and Cardiac Involvement |
| title_fullStr | Palpitations, Shortness of Breath, Weakness in Limbs, Edema, and Dyspnea: A Rare Inflammatory Myopathy with Positive Aniti-mitochondrial Antibodies and Cardiac Involvement |
| title_full_unstemmed | Palpitations, Shortness of Breath, Weakness in Limbs, Edema, and Dyspnea: A Rare Inflammatory Myopathy with Positive Aniti-mitochondrial Antibodies and Cardiac Involvement |
| title_short | Palpitations, Shortness of Breath, Weakness in Limbs, Edema, and Dyspnea: A Rare Inflammatory Myopathy with Positive Aniti-mitochondrial Antibodies and Cardiac Involvement |
| title_sort | palpitations shortness of breath weakness in limbs edema and dyspnea a rare inflammatory myopathy with positive aniti mitochondrial antibodies and cardiac involvement |
| topic | idiopathic inflammatory myopathy inflammatory myopathy associated with anti-mitochondrial antibodies heart failure cardiac arrhythmias elderly patients shared decision making |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0078 |
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