A single amino acid mutation alters multiple neutralization epitopes in the respiratory syncytial virus fusion glycoprotein

A single amino acid mutation alters multiple neutralization epitopes in the respiratory syncytial virus fusion glycoprotein

Abstract Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization. All current RSV therapeutics, including antibody prophylaxis and adult vaccination, target the RSV fusion glycoprotein (RSV-F). The seven neutralization sites on RSV-F are highly conserved and infrequently mut...

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Bibliographic Details
Main Authors: Ahmed K. Oraby, Aleksandra Stojic, Farah Elawar, Leanne M. Bilawchuk, Ryley D. McClelland, Kaci Erwin, Madison J. Granoski, Cameron D. Griffiths, Justin D. Frederick, Elena Arutyunova, M. Joanne Lemieux, Frederick. G. West, Octavio Ramilo, Asuncion Mejias, Jason S. McLellan, David J. Marchant
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-025-00119-8
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