Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia
Asthenozoospermia is a severe condition characterized by abnormal sperm motility, contributing to 50% of male infertility cases. Idiopathic asthenozoospermia refers to a form of this condition with no identifiable causes through routine clinical examinations, potentially linked to apoptosis and oxid...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1505213/full |
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| author | Zilong Wang Zilong Wang Dandan Li Guoyi Zhou Zhen Xu Xinkun Wang Senbao Tan Zhenghao Li Xiaoli Li Changze Song Song Yuan |
| author_facet | Zilong Wang Zilong Wang Dandan Li Guoyi Zhou Zhen Xu Xinkun Wang Senbao Tan Zhenghao Li Xiaoli Li Changze Song Song Yuan |
| author_sort | Zilong Wang |
| collection | DOAJ |
| description | Asthenozoospermia is a severe condition characterized by abnormal sperm motility, contributing to 50% of male infertility cases. Idiopathic asthenozoospermia refers to a form of this condition with no identifiable causes through routine clinical examinations, potentially linked to apoptosis and oxidative stress induced by excessive reactive oxygen species (ROS). At low concentrations, ROS positively influence physiological processes, including sperm mature and motility. However, elevated ROS levels can harm human spermatozoa through oxidative stress, primarily due to the absence of effective DNA damage repair mechanisms and inadequate antioxidant defenses. In this review, we summarize the physiological and pathophysiological roles, endogenous and exogenous sources, and therapeutic strategies related to ROS in idiopathic asthenozoospermia. Ultimately, maintaining a proper balance between ROS concentrations and antioxidants is crucial for ensuring male reproductive health. |
| format | Article |
| id | doaj-art-25dae2e032bf4383ac5888aad40d2fa6 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-25dae2e032bf4383ac5888aad40d2fa62025-08-20T03:13:39ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-05-011610.3389/fendo.2025.15052131505213Deciphering the role of reactive oxygen species in idiopathic asthenozoospermiaZilong Wang0Zilong Wang1Dandan Li2Guoyi Zhou3Zhen Xu4Xinkun Wang5Senbao Tan6Zhenghao Li7Xiaoli Li8Changze Song9Song Yuan10Department of Andrology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Burns and Plastic Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Radiation Therapy, Dongguan Hospital of Guangzhou University of Chinese Medicine (Dongguan Traditional Chinese Medicine Hospital), Dongguan, ChinaDepartment of Andrology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Andrology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Andrology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Andrology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Andrology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaSurgery and Anesthesia Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Andrology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaSurgery and Anesthesia Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaAsthenozoospermia is a severe condition characterized by abnormal sperm motility, contributing to 50% of male infertility cases. Idiopathic asthenozoospermia refers to a form of this condition with no identifiable causes through routine clinical examinations, potentially linked to apoptosis and oxidative stress induced by excessive reactive oxygen species (ROS). At low concentrations, ROS positively influence physiological processes, including sperm mature and motility. However, elevated ROS levels can harm human spermatozoa through oxidative stress, primarily due to the absence of effective DNA damage repair mechanisms and inadequate antioxidant defenses. In this review, we summarize the physiological and pathophysiological roles, endogenous and exogenous sources, and therapeutic strategies related to ROS in idiopathic asthenozoospermia. Ultimately, maintaining a proper balance between ROS concentrations and antioxidants is crucial for ensuring male reproductive health.https://www.frontiersin.org/articles/10.3389/fendo.2025.1505213/fullreactive oxygen speciesidiopathic asthenozoospermiaoxidative stresssperm motilityantioxidantsmale infertility |
| spellingShingle | Zilong Wang Zilong Wang Dandan Li Guoyi Zhou Zhen Xu Xinkun Wang Senbao Tan Zhenghao Li Xiaoli Li Changze Song Song Yuan Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia Frontiers in Endocrinology reactive oxygen species idiopathic asthenozoospermia oxidative stress sperm motility antioxidants male infertility |
| title | Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia |
| title_full | Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia |
| title_fullStr | Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia |
| title_full_unstemmed | Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia |
| title_short | Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia |
| title_sort | deciphering the role of reactive oxygen species in idiopathic asthenozoospermia |
| topic | reactive oxygen species idiopathic asthenozoospermia oxidative stress sperm motility antioxidants male infertility |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1505213/full |
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