The innate defenders: a review of natural killer cell immunotherapies in cancer
Cancer is a condition that has been with us for centuries; however, the therapies that have been developed are often associated with significant toxicity and various side effects. Recent advances in immunology have revealed the potential of the immune system to fight cancer, leading to the emergence...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1482807/full |
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| author | Pablo Álvarez-Carrasco Pablo Álvarez-Carrasco Carmen Maldonado-Bernal |
| author_facet | Pablo Álvarez-Carrasco Pablo Álvarez-Carrasco Carmen Maldonado-Bernal |
| author_sort | Pablo Álvarez-Carrasco |
| collection | DOAJ |
| description | Cancer is a condition that has been with us for centuries; however, the therapies that have been developed are often associated with significant toxicity and various side effects. Recent advances in immunology have revealed the potential of the immune system to fight cancer, leading to the emergence of immunotherapy. This review focuses on Natural Killer (NK) cells, innate immune effectors with a remarkable ability to directly kill cancer cells. We will explore the historical context of cancer treatment, the nature of NK cells, and the ways they have been developed to enhance their anti-tumor function, highlighting the limitations of conventional therapies. The therapeutic potential of NK cell-based immunotherapies will also be discussed, emphasizing their unique advantages over other immune cell-based approaches. This review highlights the promising future of NK cell therapies in the fight against cancer and their possible application to assist and improve conventional therapies developed so far. |
| format | Article |
| id | doaj-art-25dad5484f4a4b4d943f1ef900e67366 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-25dad5484f4a4b4d943f1ef900e673662025-08-20T01:57:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14828071482807The innate defenders: a review of natural killer cell immunotherapies in cancerPablo Álvarez-Carrasco0Pablo Álvarez-Carrasco1Carmen Maldonado-Bernal2Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Mexico City, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoLaboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Mexico City, MexicoCancer is a condition that has been with us for centuries; however, the therapies that have been developed are often associated with significant toxicity and various side effects. Recent advances in immunology have revealed the potential of the immune system to fight cancer, leading to the emergence of immunotherapy. This review focuses on Natural Killer (NK) cells, innate immune effectors with a remarkable ability to directly kill cancer cells. We will explore the historical context of cancer treatment, the nature of NK cells, and the ways they have been developed to enhance their anti-tumor function, highlighting the limitations of conventional therapies. The therapeutic potential of NK cell-based immunotherapies will also be discussed, emphasizing their unique advantages over other immune cell-based approaches. This review highlights the promising future of NK cell therapies in the fight against cancer and their possible application to assist and improve conventional therapies developed so far.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1482807/fullnatural killer cellscancerimmunotherapyactivating signalsinhibitory signalsCAR-NK cells |
| spellingShingle | Pablo Álvarez-Carrasco Pablo Álvarez-Carrasco Carmen Maldonado-Bernal The innate defenders: a review of natural killer cell immunotherapies in cancer Frontiers in Immunology natural killer cells cancer immunotherapy activating signals inhibitory signals CAR-NK cells |
| title | The innate defenders: a review of natural killer cell immunotherapies in cancer |
| title_full | The innate defenders: a review of natural killer cell immunotherapies in cancer |
| title_fullStr | The innate defenders: a review of natural killer cell immunotherapies in cancer |
| title_full_unstemmed | The innate defenders: a review of natural killer cell immunotherapies in cancer |
| title_short | The innate defenders: a review of natural killer cell immunotherapies in cancer |
| title_sort | innate defenders a review of natural killer cell immunotherapies in cancer |
| topic | natural killer cells cancer immunotherapy activating signals inhibitory signals CAR-NK cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1482807/full |
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