Microbiome drives age-dependent shifts in brain transcriptomic programs at the single-cell level in Drosophila

Abstract The gut microbiome plays a critical role in brain function and the brain-gut axis, yet its cellular and molecular mechanisms remain unclear. Here, we present the first comprehensive single-cell transcriptomic atlas of brain cells from adult Drosophila melanogaster raised under axenic and mi...

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Bibliographic Details
Main Authors: Dianshu Zhao, Russel T. Shiga, Zhangrong Song, Runhang Shu, Lipin Loo, Adam Chun Nin Wong
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-025-00781-z
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