BDNF improves fracture healing through promoting osteoblasts proliferation and migration via trkb/akt regulated NUCKS1 expression

BDNF improves fracture healing through promoting osteoblasts proliferation and migration via trkb/akt regulated NUCKS1 expression

Abstract Background Bone nonunion is a major complication in fracture treatment. Despite considerable advancements in fracture care, 5–10% of fractures result in nonunion; This demonstrates the requirement for novel molecules to enhance fracture healing. Brain-derived neurotrophic factor (BDNF) has...

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Bibliographic Details
Main Authors: Weihao Meng, Xiao Meng, Chenghua Han, Yuhe Li, Xiwen Qian, Zitao Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
BDNF
NUCKS1
Fracture healing
Proliferation
Migration
Online Access:https://doi.org/10.1038/s41598-025-11594-7
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