The effect of temperature constraints on the treatment of tumors using focused ultrasound-induced acoustic streaming
Abstract The transport of drugs into tumor cells near the center of the tumor is known to be severely hindered due to the high interstitial pressure and poor vascularization. The aim of this work is to investigate the possibility to induce acoustic streaming in a tumor. Two tumor cases (breast and a...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-83782-w |
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| author | Sebastian E. N. Price Magnus Aa. Gjennestad Signe Kjelstrup Rune Hansen |
| author_facet | Sebastian E. N. Price Magnus Aa. Gjennestad Signe Kjelstrup Rune Hansen |
| author_sort | Sebastian E. N. Price |
| collection | DOAJ |
| description | Abstract The transport of drugs into tumor cells near the center of the tumor is known to be severely hindered due to the high interstitial pressure and poor vascularization. The aim of this work is to investigate the possibility to induce acoustic streaming in a tumor. Two tumor cases (breast and abdomen) are simulated to find the acoustic streaming and temperature rise, while varying the focused ultrasound transducer radius, frequency, and power for a constant duty cycle (1%). In the absence of perfusion, the simulated rise in temperature, despite the low duty cycle, never reaches a steady state and is fitted to a logarithmic equation, enabling predictions of the temperature for long treatment times. Higher frequencies and larger probe radii are found to result in shorter treatment times relative to the temperature rise, at the cost of a smaller treated area. Results from the simulations indicate that it may be possible to achieve reasonable acoustic streaming values in tumor without the temperature exceeding 50 °C. Treatment times for streaming a distance of 50 μm in the breast case are shown to range from less than one and a half hour to 93 h, depending on the probe settings. |
| format | Article |
| id | doaj-art-25d63cb60e524c859676adeaf4f50213 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-25d63cb60e524c859676adeaf4f502132025-01-05T12:18:08ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-024-83782-wThe effect of temperature constraints on the treatment of tumors using focused ultrasound-induced acoustic streamingSebastian E. N. Price0Magnus Aa. Gjennestad1Signe Kjelstrup2Rune Hansen3Porelab and Department of Chemistry, The Norwegian University of Science and Technology NTNUSINTEF Energy ResearchPorelab and Department of Chemistry, The Norwegian University of Science and Technology NTNUSINTEF, Department of Health Research and Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology NTNUAbstract The transport of drugs into tumor cells near the center of the tumor is known to be severely hindered due to the high interstitial pressure and poor vascularization. The aim of this work is to investigate the possibility to induce acoustic streaming in a tumor. Two tumor cases (breast and abdomen) are simulated to find the acoustic streaming and temperature rise, while varying the focused ultrasound transducer radius, frequency, and power for a constant duty cycle (1%). In the absence of perfusion, the simulated rise in temperature, despite the low duty cycle, never reaches a steady state and is fitted to a logarithmic equation, enabling predictions of the temperature for long treatment times. Higher frequencies and larger probe radii are found to result in shorter treatment times relative to the temperature rise, at the cost of a smaller treated area. Results from the simulations indicate that it may be possible to achieve reasonable acoustic streaming values in tumor without the temperature exceeding 50 °C. Treatment times for streaming a distance of 50 μm in the breast case are shown to range from less than one and a half hour to 93 h, depending on the probe settings.https://doi.org/10.1038/s41598-024-83782-w |
| spellingShingle | Sebastian E. N. Price Magnus Aa. Gjennestad Signe Kjelstrup Rune Hansen The effect of temperature constraints on the treatment of tumors using focused ultrasound-induced acoustic streaming Scientific Reports |
| title | The effect of temperature constraints on the treatment of tumors using focused ultrasound-induced acoustic streaming |
| title_full | The effect of temperature constraints on the treatment of tumors using focused ultrasound-induced acoustic streaming |
| title_fullStr | The effect of temperature constraints on the treatment of tumors using focused ultrasound-induced acoustic streaming |
| title_full_unstemmed | The effect of temperature constraints on the treatment of tumors using focused ultrasound-induced acoustic streaming |
| title_short | The effect of temperature constraints on the treatment of tumors using focused ultrasound-induced acoustic streaming |
| title_sort | effect of temperature constraints on the treatment of tumors using focused ultrasound induced acoustic streaming |
| url | https://doi.org/10.1038/s41598-024-83782-w |
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