Ferrostatin-1 reduces the inflammatory response of rheumatoid arthritis by decreasing the antigen presenting function of fibroblast-like synoviocytes

Ferrostatin-1 reduces the inflammatory response of rheumatoid arthritis by decreasing the antigen presenting function of fibroblast-like synoviocytes

Abstract Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease with complex mechanism. Currently, ferroptosis is believed to play a role in it, but the specific mechanism is unknown, especially in immune response. In this study, we demonstrated that the high expression of major histocom...

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Bibliographic Details
Main Authors: Xiaoying Zhu, Hanya Lu, Haonan Jia, Xuemin Wei, Jiawei Xue, Wenjing Li, Juan Zhang, Yanli Wang, Jingyao Yan, Haoyuan Sun, Yanlei Ge, Zhiyi Zhang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Rheumatoid arthritis
Ferroptosis
Immune
Antigen presentation
Inflammation
Online Access:https://doi.org/10.1186/s12967-025-06300-0
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