BMP2 enhance the osteogenic effect of BMSCs-derived exosomes in skull defect of diabetic rats

BMP2 enhance the osteogenic effect of BMSCs-derived exosomes in skull defect of diabetic rats

Diabetic patients often face poor repair of bone defects, which may be related to the reduced osteogenic capacity of bone marrow mesenchymal stem cells (BMSCs) and the polarization of M1/M2 macrophage imbalance leading to an inflammatory response. The ability of BMSC-derived exosomes (BMSC-Exos) and...

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Bibliographic Details
Main Authors: Yilin He, Yihu Wang, Shujia Yu, Lingxiao Wang, Yiping Dou, Ruihong Ma, Shiyu Cao, Wenpeng Song, Pan Ma
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Materials & Design
Subjects:
Bone morphogenetic protein 2
Bone regeneration
Diabetes
Bone marrow mesenchymal stem cells
Exosomes
PI3K/AKT signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S026412752400892X
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