Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
Abstract Several vaccines are approved in the United States for seasonal influenza vaccination every year. Here we compare the impact of repeat influenza vaccination on hemagglutination inhibition (HI) titers, antibody binding and affinity maturation to individual hemagglutinin (HA) domains, HA1 and...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11296-5 |
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| author | Surender Khurana Megan Hahn Elizabeth M. Coyle Lisa R. King Tsai-Lien Lin John Treanor Andrea Sant Hana Golding |
| author_facet | Surender Khurana Megan Hahn Elizabeth M. Coyle Lisa R. King Tsai-Lien Lin John Treanor Andrea Sant Hana Golding |
| author_sort | Surender Khurana |
| collection | DOAJ |
| description | Abstract Several vaccines are approved in the United States for seasonal influenza vaccination every year. Here we compare the impact of repeat influenza vaccination on hemagglutination inhibition (HI) titers, antibody binding and affinity maturation to individual hemagglutinin (HA) domains, HA1 and HA2, across vaccine platforms. Fold change in HI and antibody binding to HA1 trends higher for H1N1pdm09 and H3N2 but not against B strains in groups vaccinated with FluBlok compared with FluCelvax and Fluzone. Antibody-affinity maturation occurs against HA1 domain of H1N1pdm09, H3N2 and B following vaccination with all vaccine platforms, but not against H1N1pdm09-HA2. Importantly, prior year vaccination of subjects receiving repeat vaccinations demonstrated reduced antibody-affinity maturation to HA1 of all three influenza virus strains irrespective of the vaccine platform. This study identifies an important impact of repeat vaccination on antibody-affinity maturation following vaccination, which may contribute to lower vaccine effectiveness of seasonal influenza vaccines in humans |
| format | Article |
| id | doaj-art-25c5be5b8b3340e9bfab6fabc559795c |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-25c5be5b8b3340e9bfab6fabc559795c2025-08-20T03:05:14ZengNature PortfolioNature Communications2041-17232019-07-0110111510.1038/s41467-019-11296-5Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humansSurender Khurana0Megan Hahn1Elizabeth M. Coyle2Lisa R. King3Tsai-Lien Lin4John Treanor5Andrea Sant6Hana Golding7Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Biostatistics, Center for Biologics Evaluation and Research (CBER), FDAUniversity of Rochester Medical CenterUniversity of Rochester Medical CenterDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDAAbstract Several vaccines are approved in the United States for seasonal influenza vaccination every year. Here we compare the impact of repeat influenza vaccination on hemagglutination inhibition (HI) titers, antibody binding and affinity maturation to individual hemagglutinin (HA) domains, HA1 and HA2, across vaccine platforms. Fold change in HI and antibody binding to HA1 trends higher for H1N1pdm09 and H3N2 but not against B strains in groups vaccinated with FluBlok compared with FluCelvax and Fluzone. Antibody-affinity maturation occurs against HA1 domain of H1N1pdm09, H3N2 and B following vaccination with all vaccine platforms, but not against H1N1pdm09-HA2. Importantly, prior year vaccination of subjects receiving repeat vaccinations demonstrated reduced antibody-affinity maturation to HA1 of all three influenza virus strains irrespective of the vaccine platform. This study identifies an important impact of repeat vaccination on antibody-affinity maturation following vaccination, which may contribute to lower vaccine effectiveness of seasonal influenza vaccines in humanshttps://doi.org/10.1038/s41467-019-11296-5 |
| spellingShingle | Surender Khurana Megan Hahn Elizabeth M. Coyle Lisa R. King Tsai-Lien Lin John Treanor Andrea Sant Hana Golding Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans Nature Communications |
| title | Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| title_full | Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| title_fullStr | Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| title_full_unstemmed | Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| title_short | Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| title_sort | repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| url | https://doi.org/10.1038/s41467-019-11296-5 |
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