LILRA5+ macrophages drive early oxidative stress surge in sepsis: a single-cell transcriptomic landscape with therapeutic implications

LILRA5+ macrophages drive early oxidative stress surge in sepsis: a single-cell transcriptomic landscape with therapeutic implications

BackgroundIn sepsis, oxidative stress (OS) triggers essential adaptive responses and emerging OS-related biomarkers show potential for enhancing sepsis diagnosis and therapy.MethodologyIn this study, we used single-cell datasets and the OS gene set to identify immune cell types with the highest oxid...

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Bibliographic Details
Main Authors: Peng Xu, Haoze Li, Zuo Tao, Zixuan Zhang, Xiaohuan Wang, Cheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
oxidative stress
sepsis
LILRA5
macrophage
single-cell
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1606401/full
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