Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics
Cancer is one of the leading causes of death worldwide. Many therapies are being used to treat this disease, however, new treatments are now being implemented, since they are not always effective and their secondary effects represent one of the main reasons for cancer patients’ loss of life quality...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1540217/full |
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| author | Iera Hernandez-Unzueta Uxue Telleria-Gonzalez Ana María Aransay Ana María Aransay José Ezequiel Martin Rodriguez Eduardo Sanz Joana Márquez |
| author_facet | Iera Hernandez-Unzueta Uxue Telleria-Gonzalez Ana María Aransay Ana María Aransay José Ezequiel Martin Rodriguez Eduardo Sanz Joana Márquez |
| author_sort | Iera Hernandez-Unzueta |
| collection | DOAJ |
| description | Cancer is one of the leading causes of death worldwide. Many therapies are being used to treat this disease, however, new treatments are now being implemented, since they are not always effective and their secondary effects represent one of the main reasons for cancer patients’ loss of life quality during the progression of the disease. In this scenario, Ocoxin is a mixture of plant extracts, amino acids, vitamins and minerals, known for its antioxidant, anti-inflammatory and immunoregulatory properties, which has shown to exert antitumor effects in many cancers. The aim of this study is to elucidate the mechanism of action of the compound in colorectal cancer, triple negative breast cancer, pancreatic cancer and prostate cancer. Analyses performed through RNA sequencing revealed that the main effect of Ocoxin appears to be the alteration of cell metabolism, especially inducing the process of ferroptosis. Nevertheless, the modulation of the cell cycle was also remarkable. Ocoxin altered 13 genes in common in all the four cancers that were not only associated to metabolism and cell cycle but were also involved in the integrated stress response and unfolded protein response, suggesting that the compound causes the induction of cell death through several pathways. Although the mechanisms vary according to the type of cancer, this study highlights the potential of Ocoxin as an adjunctive treatment to improve outcomes in cancer therapy. |
| format | Article |
| id | doaj-art-25bf5f3d05384c5b82507bd97b091f96 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-25bf5f3d05384c5b82507bd97b091f962025-08-20T03:02:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-03-011610.3389/fphar.2025.15402171540217Unravelling the antitumor mechanism of Ocoxin through cancer cell genomicsIera Hernandez-Unzueta0Uxue Telleria-Gonzalez1Ana María Aransay2Ana María Aransay3José Ezequiel Martin Rodriguez4Eduardo Sanz5Joana Márquez6Cell Biology and Histology Department, Faculty of Medicine and Nursing, University of the Basque Country, Leioa, SpainCell Biology and Histology Department, Faculty of Medicine and Nursing, University of the Basque Country, Leioa, SpainGenome Analysis Platform, CIC Biogune, Derio, SpainCIBERehd, Instituto de Salud Carlos III, Madrid, SpainGenome Analysis Platform, CIC Biogune, Derio, SpainCatalysis S.L., Madrid, SpainCell Biology and Histology Department, Faculty of Medicine and Nursing, University of the Basque Country, Leioa, SpainCancer is one of the leading causes of death worldwide. Many therapies are being used to treat this disease, however, new treatments are now being implemented, since they are not always effective and their secondary effects represent one of the main reasons for cancer patients’ loss of life quality during the progression of the disease. In this scenario, Ocoxin is a mixture of plant extracts, amino acids, vitamins and minerals, known for its antioxidant, anti-inflammatory and immunoregulatory properties, which has shown to exert antitumor effects in many cancers. The aim of this study is to elucidate the mechanism of action of the compound in colorectal cancer, triple negative breast cancer, pancreatic cancer and prostate cancer. Analyses performed through RNA sequencing revealed that the main effect of Ocoxin appears to be the alteration of cell metabolism, especially inducing the process of ferroptosis. Nevertheless, the modulation of the cell cycle was also remarkable. Ocoxin altered 13 genes in common in all the four cancers that were not only associated to metabolism and cell cycle but were also involved in the integrated stress response and unfolded protein response, suggesting that the compound causes the induction of cell death through several pathways. Although the mechanisms vary according to the type of cancer, this study highlights the potential of Ocoxin as an adjunctive treatment to improve outcomes in cancer therapy.https://www.frontiersin.org/articles/10.3389/fphar.2025.1540217/fullOcoxincancerplant extractferroptosisadjuvantchemotherapy |
| spellingShingle | Iera Hernandez-Unzueta Uxue Telleria-Gonzalez Ana María Aransay Ana María Aransay José Ezequiel Martin Rodriguez Eduardo Sanz Joana Márquez Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics Frontiers in Pharmacology Ocoxin cancer plant extract ferroptosis adjuvant chemotherapy |
| title | Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics |
| title_full | Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics |
| title_fullStr | Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics |
| title_full_unstemmed | Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics |
| title_short | Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics |
| title_sort | unravelling the antitumor mechanism of ocoxin through cancer cell genomics |
| topic | Ocoxin cancer plant extract ferroptosis adjuvant chemotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1540217/full |
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