Bioinformatics analysis of coronary microvascular dysfunction in rats based on single-cell RNA sequencing

Bioinformatics analysis of coronary microvascular dysfunction in rats based on single-cell RNA sequencing

Abstract Coronary microvascular dysfunction serves as one of the etiological factors for ischemic heart disease and represents a novel therapeutic direction for coronary artery diseases; however, the research on its pathogenesis remains inconsistent. This study aims to explore the single-cell gene e...

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Main Authors: Hao Li, Yiding Jia, Zelin Chen, Luqun Yang, Lin Ni, Yuchen Cao, Rong Fan, Zitong Yuan, Kaiyi Zhu, Zhijun Zhang, Lin Zuo, Ping Wu, Yuping Gao, Yuanyuan Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Coronary microvascular dysfunction
Single-cell RNA sequencing
Bioinformatics analysis
Endothelial cells
Endothelial-to-mesenchymal transition
Online Access:https://doi.org/10.1038/s41598-025-85318-2
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