N6-methyladenosine in DNA promotes genome stability

N6-methyladenosine in DNA promotes genome stability

DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a chemotherapeutic agent that incorporates uracil and...

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Bibliographic Details
Main Authors: Brooke A Conti, Leo Novikov, Deyan Tong, Qing Xiang, Savon Vigil, Thomas J McLellan, Chuong Nguyen, Nancy De La Cruz, Reshma T Veettil, Prashant Pradhan, Parag Sahasrabudhe, Jason D Arroyo, Lei Shang, Benjamin R Sabari, David J Shields, Mariano Oppikofer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
N6-methyladenosine
6mA
U-BER
MMR
UNG
METTL3
Online Access:https://elifesciences.org/articles/101626
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