PFKFB3 Connects Glycolytic Metabolism with Endothelial Dysfunction in Human and Rodent Obesity

PFKFB3 Connects Glycolytic Metabolism with Endothelial Dysfunction in Human and Rodent Obesity

Obesity and type 2 diabetes (T2D) increase cardiovascular risk, largely due to altered metabolic state. An early consequence of T2D/obesity is the loss of endothelial function and impaired nitric oxide (NO) signaling. In blood vessels, endothelial nitric oxide synthase (eNOS) synthesizes NO to maint...

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Bibliographic Details
Main Authors: Robert K. Batori, Zsuzsanna Bordan, Caleb A. Padgett, Yuqing Huo, Feng Chen, Reem T. Atawia, Rudolf Lucas, Masuko Ushio-Fukai, Tohru Fukai, Eric J. Belin de Chantemele, David W. Stepp, David J. R. Fulton
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Antioxidants
Subjects:
PFKFB3
eNOS
nitric oxide
ROS
NOX1
NOX5
Online Access:https://www.mdpi.com/2076-3921/14/2/172
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